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Titolo:
Mechanics of the carotid artery wall and baroreflex sensitivity after acute ethanol administration in young healthy volunteers
Autore:
Fazio, M; Bardelli, M; Macaluso, L; Fiammengo, F; Mattei, PL; Bossi, M; Fabris, B; Fischetti, F; Pascazio, L; Candido, R; Carretta, R;
Indirizzi:
Univ Trieste, Dept Clin Med, Osped Cattinara, I-34149 Trieste, Italy Univ Trieste Trieste Italy I-34149 ped Cattinara, I-34149 Trieste, Italy Univ Trieste, Osped Cattinara, Chair Geriatr, I-34149 Trieste, Italy Univ Trieste Trieste Italy I-34149 Chair Geriatr, I-34149 Trieste, Italy
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 3, volume: 101, anno: 2001,
pagine: 253 - 260
SICI:
0143-5221(200109)101:3<253:MOTCAW>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE; ALCOHOL INGESTION; BLOOD-PRESSURE; BARORECEPTORS; ENDOTHELIUM; HYPERTENSION; IMPAIRMENT; FLOW;
Keywords:
carotid baroreflex; ethanol; mechanics; shear stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Carretta, R Univ Trieste, Dept Clin Med, Osped Cattinara, I-34149 Trieste,Italy Univ Trieste Trieste Italy I-34149 a, I-34149 Trieste, Italy
Citazione:
M. Fazio et al., "Mechanics of the carotid artery wall and baroreflex sensitivity after acute ethanol administration in young healthy volunteers", CLIN SCI, 101(3), 2001, pp. 253-260

Abstract

The effects of ethanol administered orally (300 mg/kg in 250 ml of water) or intravenously (7.5 mg(.)min(-1.)kg(-1) in 250 ml of saline over 40 min) on common carotid haemodynamics, wall mechanics and baroreflex sensitivity were compared with the effects of the intravenous infusion of 250 ml of saline. Ethanol or saline was administered to 10 healthy volunteers after 30 min of supine rest, and measurements were obtained 40 min (median; range 34-46 min) after administration. After ethanol administration, the plasma alcohol level rose from 0 to 0.3 +/- 0.07 g/l. Mean arterial blood pressure hadrisen slightly at 20 min, but was normalized by 40 min, the time at which the haemodynamic study was performed. Heart rate decreased after infusion of either saline or alcohol, but was unchanged after oral ethanol administration. Both oral and intravenous ethanol administration were associated withsignificant decreases in baroreflex sensitivity, carotid shear stress and blood velocity, compared with resting values, while the mean carotid arterydiameter was increased, and blood viscosity and mean blood flow were unchanged. No changes were observed in these parameters after saline administration. Ethanol, administered either intravenously or orally, increased the stiffness of the carotid artery and decreased the pulsatility (systo-diastolic changes) of its diameter. A direct, statistically significant correlationwas found between the decrease in shear stress and the decrease in baroreflex heart rate control sensitivity after both modes of alcohol administration, while no such correlation was found between the increase in the Peterson elastic modulus and the decrease in carotid diameter pulsatility on the one hand or the decrease in baroreflex sensitivity on the other. In conclusion, reduced shear stress associated with vasodilatation of the carotid artery wall may contribute to the decrease in baroreflex sensitivity observed after acute ethanol administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:57:06