Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Platelet-endothelial cell adhesion molecule-1 (CD31) redistributes from the endothelial junction and is not required for the transendothelial migration of melanoma cells
Autore:
Voura, EB; Chen, N; Siu, CH;
Indirizzi:
Univ Toronto, Charles H Best Inst, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada Univ Toronto Toronto ON Canada M5G 1L6 d Res, Toronto, ON M5G 1L6, Canada Univ Toronto, Dept Biochem, Toronto, ON M5G 1L6, Canada Univ Toronto Toronto ON Canada M5G 1L6 ochem, Toronto, ON M5G 1L6, Canada
Titolo Testata:
CLINICAL & EXPERIMENTAL METASTASIS
fascicolo: 6, volume: 18, anno: 2001,
pagine: 527 - 532
SICI:
0262-0898(2001)18:6<527:PCAM(R>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; LEUKOCYTE TRANSMIGRATION; NEUTROPHIL RECRUITMENT; ADHERENS JUNCTIONS; PECAM-1; VITRO; INHIBITION; METASTASIS; CADHERINS; MONOCYTES;
Keywords:
antibody inhibition; CD31; confocal microscopy; metastasis; PECAM-1; transendothelial migration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Siu, CH Univ Toronto, Charles H Best Inst, Banting & Best Dept Med Res, 112 Coll St, Toronto, ON M5G 1L6, Canada Univ Toronto 112 Coll St Toronto ON Canada M5G 1L6 M5G 1L6, Canada
Citazione:
E.B. Voura et al., "Platelet-endothelial cell adhesion molecule-1 (CD31) redistributes from the endothelial junction and is not required for the transendothelial migration of melanoma cells", CLIN EXP M, 18(6), 2001, pp. 527-532

Abstract

We have examined the role of platelet-endothelial cell adhesion molecule-1(PECAM-1/CD31) during the transendothelial migration of melanoma cells using a novel in vitro system. Comparable studies have suggested the involvement of PECAM-1 in leukocyte transendothelial migration. Such studies have been confirmed using in vivo models of inflammation. These studies prompted us to examine the role of PECAM-1 in tumor cell transendothelial migration. Anti-PECAM-1 monoclonal antibodies, known to block leukocyte transendothelial migration, were tested in co-cultures of human melanoma cells seeded on a monolayer of human lung microvascular endothelial cells. None of these antibodies inhibited the transmigration of melanoma cells. Moreover, confocalmicroscopy revealed the dissolution of the PECAM-1 adhesion complexes in the endothelial junctions associated with melanoma cells and the lack of PECAM-1 in heterotypic contacts between transmigrating melanoma cells and adjacent endothelial cells. These data, therefore, indicate that PECAM-1 is notrequired for the transendothelial migration of melanoma cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:55:42