Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions - The Atherosclerosis Risk in Communities (ARIC) Study
Autore:
Sharrett, AR; Ballantyne, CM; Coady, SA; Heiss, G; Sorlie, PD; Catellier, D; Patsch, W;
Indirizzi:
NHLBI, Epidemiol & Biometry Program, NIH, DECA, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 ry Program, NIH, DECA, Bethesda, MD 20892 USA Baylor Coll Med, Dept Med, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Med, Dept Med, Houston, TX 77030 USA Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA a, Sch Publ Hlth, Chapel Hill, NC USA Landeskrankenanstalten Salzburg, Dept Lab Med, Salzburg, Austria Landeskrankenanstalten Salzburg Salzburg Austria Med, Salzburg, Austria
Titolo Testata:
CIRCULATION
fascicolo: 10, volume: 104, anno: 2001,
pagine: 1108 - 1113
SICI:
0009-7322(20010904)104:10<1108:CHDPFL>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-INFARCTION; ARTERY DISEASE; FOLLOW-UP; MEN; PLASMA; PREVENTION; HYPERTRIGLYCERIDEMIA; RADIOIMMUNOASSAY; QUANTITATION; ASSOCIATION;
Keywords:
lipoproteins; apolipoproteins; coronary disease; follow-up studies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Sharrett, AR NHLBI, Epidemiol & Biometry Program, NIH, DECA, 2 Rockledge Ctr,Room 8164,6701 Rockledge Dr,MSC 7, Bethesda, MD 20892 USA NHLBI 2 Rockledge Ctr,Room 8164,6701 Rockledge Dr,MSC 7 Bethesda MD USA 20892
Citazione:
A.R. Sharrett et al., "Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions - The Atherosclerosis Risk in Communities (ARIC) Study", CIRCULATION, 104(10), 2001, pp. 1108-1113

Abstract

Background-Despite consensus on the need for blood cholesterol reductions to prevent coronary heart disease (CHD), available evidence on optimal cholesterol levels or the added predictive value of additional lipids is sparse. Methods and Results-After 10 years follow-up of 12 339 middle-aged participants free of CHD in the Atherosclerosis Risk in Communities Study (ARIC), 725 CHD events occurred. The lowest incidence was observed in those at the lowest LDL cholesterol (LDL-C) quintile, with medians of 88 mg/dL in women and 95 mg/dL in men, and risk accelerated at higher levels, with relative risks (RRs) for the highest quintile of 2.7 in women and 2.5 in men. LDL-C, HDL-C, lipoprotein(a) [Lp(a)], and in women but not men, triglycerides (TG)were all independent CHD predictors, providing an RR, together with blood pressure, smoking, and diabetes, of 13.5 in women and 4.9 in men. Lp(a) wasless significant in blacks than whites. Prediction was not enhanced by HDL-C density subfractions or apolipoproteins (apo) A-I or B. Despite strong univariate associations, apoB did not contribute to risk prediction in subgroups with elevated TG, with lower LDL-C, or with high apoB relative to LDL-C. Conclusions-Optimal LDL-C values are <100 mg/dL in both women and men. LDL-C, HDL-C, TG, and Lp(a), without additional apolipoproteins or lipid subfractions, provide substantial CHD prediction, with much higher RR in women than men.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:48:38