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Titolo:
Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function
Autore:
Choi, KA; Kim, RJ; Gubernikoff, G; Vargas, JD; Parker, M; Judd, RA;
Indirizzi:
Northwestern Univ, Sch Med, Feinberg Cardiovasc Res Inst, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 sc Res Inst, Chicago, IL 60611 USA Northwestern Univ, Sch Med, Dept Med, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 d, Dept Med, Chicago, IL 60611 USA Northwestern Univ, Sch Med, Dept Biomed Engn, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Biomed Engn, Chicago, IL 60611 USA
Titolo Testata:
CIRCULATION
fascicolo: 10, volume: 104, anno: 2001,
pagine: 1101 - 1107
SICI:
0009-7322(20010904)104:10<1101:TEOAMI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY REPERFUSION; COMBINATION THROMBOLYTIC THERAPY; ISCHEMIC CELL-DEATH; CREATINE-KINASE; PLASMINOGEN-ACTIVATOR; VENTRICULAR-FUNCTION; WAVEFRONT PHENOMENON; IRREVERSIBLE INJURY; RANDOMIZED TRIAL; SIZE;
Keywords:
magnetic resonance imaging; contrast media; myocardial infarction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Judd, RA Northwestern Univ, Sch Med, Feinberg Cardiovasc Res Inst, 303 E Chicago Ave,Tarry 12-723, Chicago, IL 60611 USA Northwestern Univ 303 E Chicago Ave,Tarry 12-723 Chicago IL USA 60611
Citazione:
K.A. Choi et al., "Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function", CIRCULATION, 104(10), 2001, pp. 1101-1107

Abstract

Background-Previous animal studies have demonstrated that the transmural extent of acute myocardial infarction defined by contrast-enhanced MRI (ceMRI) relates to early restoration of flow and future improvements in contractile function. We tested the hypothesis that ceMRI would have similar predictive value in humans. Methods and Results-Twenty-four patients who presented with their first myocardial infarction and were successfully revascularized underwent cine andceMRI of their heart within 7 days (scan 1) of the peak MB band of creatine kinase. Cine MRI was repeated 8 to 12 weeks later (scan 2). The transmural extent of infarction on scan I and wall thickening on both scans were determined using a 72-segment model. A total of 524 of 1571 segments (33%) were dysfunctional on scan 1. Improvement in segmental contractile function onscan 2 was inversely related to the transmural extent of infarction on scan 1 (P=0.001). Improvement in global contractile function, as assessed by ejection fraction and mean wall thickening score, was not predicted by peak creatine kinase-MB (P=0.66) or by total infarct size, as defined by MRI (P=0.70). The best predictor of global improvement was the extent of dysfunctional myocardium that was not infarcted or had infarction comprising <25% ofleft ventricular wall thickness (P<0.005 for ejection fraction, P<0.001 for mean wall thickening score). Conclusion-In patients with acute myocardial infarction, the transmural extent of infarction defined by ceMRI predicts improvement in contractile function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:14:47