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Titolo:
Expression and localization of leptin receptor in the normal rat pituitarygland
Autore:
Sone, M; Nagata, H; Takekoshi, S; Osamura, RY;
Indirizzi:
Tokai Univ, Sch Med, Dept Pathol, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan
Titolo Testata:
CELL AND TISSUE RESEARCH
fascicolo: 3, volume: 305, anno: 2001,
pagine: 351 - 356
SICI:
0302-766X(200109)305:3<351:EALOLR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE SECRETION; FORM SPLICE-VARIANT; OBESE GENE-PRODUCT; NORMAL FEMALE MICE; ANTERIOR-PITUITARY; IMMUNOHISTOCHEMICAL LOCALIZATION; MESSENGER-RNA; GH SECRETION; INTERLEUKIN-6; RELEASE;
Keywords:
leptin; leptin receptor; leptin-R; immunohistochemistry; pituitary gland; rat (Wistar);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Osamura, RY Tokai Univ, Sch Med, Dept Pathol, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 gawa 2591193, Japan
Citazione:
M. Sone et al., "Expression and localization of leptin receptor in the normal rat pituitarygland", CELL TIS RE, 305(3), 2001, pp. 351-356

Abstract

Leptin receptor (leptin-R) is a polypeptide consisting of a single transmembrane-spanning component. Recent studies performed by reverse transcriptase polymerase chain reaction (RT-PCR) have shown the production of leptin-R in various tissues including the pituitary, hypothalamus and reproductive organs. The localization of leptin-R protein in the pituitary gland, however, has not been extensively studied. This study deals with the expression ofleptin-R in the normal rat pituitary gland, which was disclosed primarily in the plasma membrane fraction by immunoblotting and immuno-histochemical staining methods. Double immunohistochemical staining revealed that the colocalization of leptin-R and anterior pituitary hormone expression was seen mainly in growth hormone (GH)-secreting cells (97.4 +/-1.3%; GH-positive cells/leptin-R-positive cells), but in less than 1% of prolactin (PRL)-, adrenocorticotropic hormone (ACTH)-, thyroid-stimulating hormone-beta (TSH beta)- and follicle-stimulating hormone-beta (FSH beta)/luteinizing hormone-beta (LH beta)-positive cells. In contrast, leptin was localized most frequently in FSH beta /LH beta- and less frequently in TSH beta -positive cells. The above findings suggest that, in the rat anterior pituitary gland, there are paracrine relationships between leptin-producing cells and cells with leptin-R, which may regulate the function of GH cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:18:53