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Titolo:
TATA binding protein-associated CK2 transduces DNA damage, signals to the RNA polymerase III transcriptional machinery
Autore:
Ghavidel, A; Schultz, MC;
Indirizzi:
Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 hem, Edmonton, AB T6G 2H7, Canada
Titolo Testata:
CELL
fascicolo: 5, volume: 106, anno: 2001,
pagine: 575 - 584
SICI:
0092-8674(20010907)106:5<575:TBPCTD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CASEIN KINASE-II; SACCHAROMYCES-CEREVISIAE; CELL-CYCLE; BETA-SUBUNIT; GENE; YEAST; CHECKPOINT; PROMOTERS; CKII; TBP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Schultz, MC Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 n, AB T6G 2H7, Canada
Citazione:
A. Ghavidel e M.C. Schultz, "TATA binding protein-associated CK2 transduces DNA damage, signals to the RNA polymerase III transcriptional machinery", CELL, 106(5), 2001, pp. 575-584

Abstract

Here we report that RNA polymerase (pol) III transcription is repressed inresponse to DNA damage by downregulation of TFIIIB, the core component of the pol III transcriptional machinery. Protein kinase CK2 transduces this stress signal to TFIIIB. CK2 associates with and normally activates the TATAbinding protein (TBP) subunit of TFIIIB. The beta regulatory subunit of CK2 binds to TBP and is required for high TBP-associated CK2 activity and polIII transcription in unstressed cells. Transcriptional repression induced by DNA damage requires CK2 and coincides with downregulation of TBP-associated CK2 and dissociation of catalytic subunits from TBP-CK2 complexes. Therefore, CK2 is the terminal effector in a signaling pathway that represses pol III transcription when genome integrity is compromised.

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Documento generato il 25/11/20 alle ore 07:24:50