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Titolo:
Human prostate cancer cells adhere specifically to hemoglobin: a possible role in bone-specific metastasis
Autore:
Kawai, N; Kunimatsu, M; Tozawa, K; Sasaki, M; Kohri, K;
Indirizzi:
Nagoya City Univ, Sch Med, Dept Urol, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Dept Biochem 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan
Titolo Testata:
CANCER LETTERS
fascicolo: 2, volume: 171, anno: 2001,
pagine: 201 - 207
SICI:
0304-3835(20011010)171:2<201:HPCCAS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELATED PROTEIN; MOLECULE E-CADHERIN; ADHESION MOLECULES; CARCINOMA; BREAST; MARROW; LINE; EXPRESSION; MATRIX; ESTABLISHMENT;
Keywords:
prostate; cancer; bone metastasis; hemoglobin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kawai, N Nagoya City Univ, Sch Med, Dept Urol, Mizuho Ku, 1 Kawasumi,Mizuho Cho, Nagoya, Aichi 4678601, Japan Nagoya City Univ 1 Kawasumi,Mizuho Cho Nagoya Aichi Japan 4678601
Citazione:
N. Kawai et al., "Human prostate cancer cells adhere specifically to hemoglobin: a possible role in bone-specific metastasis", CANCER LETT, 171(2), 2001, pp. 201-207

Abstract

From the supernatant of rabbit bone marrow, we isolated an organ-specific factor, which was related with the metastasis of prostate cancer to the bone and examined its adhesion to prostate cancer cells (PC-3). Molecular weight and amino acid sequence analyses of the active component obtained by high performance liquid chromatography revealed that a component identical to the alpha chain of hemoglobin accounted for 80% of the biological activity. Hemoglobin showed over 50% adhesion to PC-3 cells but only 10% adhesion tohuman colon cancer cell lines, representative of organ non-specific metastasis, and leukemia cells line, representative of a non-solid tumor. Some substance in the bone marrow may promote the first step of adhesion of cancercells to bone marrow in the metastasis of prostate cancer to the bone. possibly an amino acid sequence or some tertiary structure similar to hemoglobin. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:03:59