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Titolo:
Tumor cell differentiation by butyrate and environmental stress
Autore:
Witt, O; Schulze, S; Kanbach, K; Roth, C; Pekrun, A;
Indirizzi:
Univ Gottingen, Childrens Hosp, D-37075 Gottingen, Germany Univ GottingenGottingen Germany D-37075 osp, D-37075 Gottingen, Germany
Titolo Testata:
CANCER LETTERS
fascicolo: 2, volume: 171, anno: 2001,
pagine: 173 - 182
SICI:
0304-3835(20011010)171:2<173:TCDBBA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-KINASE; INDUCED ERYTHROID-DIFFERENTIATION; P38 MAP KINASE; SODIUM-BUTYRATE; LEUKEMIC-CELLS; PC12 CELLS; INHIBITION; SHOCK; INDUCTION; HYPERTHERMIA;
Keywords:
butyrate; p38 MAPkinase; differentiation; stress signaling; heat shock; hyperosmolarity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Witt, O Univ Gottingen, Childrens Hosp, Robert Koch St 40, D-37075 Gottingen, Germany Univ Gottingen Robert Koch St 40 Gottingen Germany D-37075 ermany
Citazione:
O. Witt et al., "Tumor cell differentiation by butyrate and environmental stress", CANCER LETT, 171(2), 2001, pp. 173-182

Abstract

The present study shows that stress signaling plays a role in differentiation of K562. PANC1, HT29 and HL60 tumor cells: (1) Butyrate induced differentiation in K562, PANC1 and HT29 cells can be inhibited by SB203580. a specific inhibitor of p38 stress activated protein kinase. (2) Heat shock and hyperosmolarity increase expression of differentiation markers in K562. HT29, HL60 and in K562, PANC1, and HT29 cells, respectively. (3) Conversely. environmental stress induced differentiation in K562, HT29. and PANC1 cells can be inhibited by SB203580 and quercetin, a compound with heat shock pathway inhibiting activity. (4) Butyrate and environmental stress enhance either additively or synergistically differentiation of K562, HT29. PANC1 or HL60 cells, respectively. Stress signaling pathways might be an interesting pharmacologic target for differentiation therapy of malignant disease. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:26:31