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Titolo:
Prostaglandin D-2 is a potent chemoattractant for human eosinophils that acts via a novel DIP receptor
Autore:
Monneret, G; Gravel, S; Diamond, M; Rokach, J; Powell, WS;
Indirizzi:
McGill Univ, Meakins Christie Labs, Dept Med, Montreal, PQ H2X 2P2, CanadaMcGill Univ Montreal PQ Canada H2X 2P2 Med, Montreal, PQ H2X 2P2, Canada Florida Inst Technol, Dept Chem, Melbourne, FL 32901 USA Florida Inst Technol Melbourne FL USA 32901 Chem, Melbourne, FL 32901 USA Florida Inst Technol, Claude Pepper Inst, Melbourne, FL 32901 USA Florida Inst Technol Melbourne FL USA 32901 Inst, Melbourne, FL 32901 USA
Titolo Testata:
BLOOD
fascicolo: 6, volume: 98, anno: 2001,
pagine: 1942 - 1948
SICI:
0006-4971(20010915)98:6<1942:PDIAPC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-OXO-6,8,11,14-EICOSATETRAENOIC ACID; PROSTANOID RECEPTORS; HUMAN NEUTROPHILS; L-SELECTIN; HUMAN-PLATELETS; HUMAN AIRWAYS; D SYNTHETASE; MAST-CELLS; INHIBITION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Powell, WS McGill Univ, Meakins Christie Labs, Dept Med, 3626 St Urbain St, Montreal,PQ H2X 2P2, Canada McGill Univ 3626 St Urbain St Montreal PQ Canada H2X 2P2 Canada
Citazione:
G. Monneret et al., "Prostaglandin D-2 is a potent chemoattractant for human eosinophils that acts via a novel DIP receptor", BLOOD, 98(6), 2001, pp. 1942-1948

Abstract

Prostaglandin D-2 (PGD(2)) is released following exposure of asthmatics toallergen and acts via the adenylyl cyclase-coupled receptor for PGD(2) (DID receptor). In this study, it is reported that human eosinophils possess this receptor, which would be expected to inhibit their activation. In contrast, it was found that prostaglandin D-2 is a potent stimulator of eosinophil chemotaxis, actin polymerization, CD11b expression, and L-selectin shedding. These responses are specific for eosinophils, as neutrophils display little or no response to prostaglandin D-2 They were not due to interaction with receptors for other prostanoids, as prostaglandins E-2 and F-2 alpha, U46619 (a thromboxane A(2) analogue), and carbaprostacyclin (a prostacyclinanalogue) displayed little or no activity. Furthermore, they were not shared by the selective DID receptor agonist BW245C and were not prevented by the selective DID receptor antagonist BWA868C, indicating that they were notmediated by DID receptors. In contrast, the prostaglandin D2 metabolite 13,14-dihydro-15-oxoprostaglandin D-2 induced eosinophil activation but did not stimulate DID receptor-mediated adenosine 3 ' ,5 ' -cyclic monophosphate(cAMP) formation. These results indicate that in addition to the classic inhibitory DID, receptor, eosinophils possess a second, novel DP2 receptor that is associated with PGD(2)-induced cell activation. These 2 receptors appear to interact to regulate eosinophil responses to PGD(2), as blockade ofDPI receptor-mediated cAMP production by BWA868C resulted in enhanced DP2 receptor-mediated stimulation of CD11b expression. The balance between DPI and DP2 receptors could determine the degree to which prostaglandin D-2 canactivate eosinophils and may play a role in eosinophil recruitment in asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:25:56