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Titolo:
The association of androgen- and oestrogen-receptor gene polymorphisms with urolithiasis in men
Autore:
Chen, WC; Wu, HC; Lin, WC; Wu, MC; Hsu, CD; Tsai, FJ;
Indirizzi:
China Med Coll Hosp, Dept Med Genet, Taichung 404, Taiwan China Med Coll Hosp Taichung Taiwan 404 Med Genet, Taichung 404, Taiwan China Med Coll Hosp, Dept Urol, Taichung, Taiwan China Med Coll Hosp Taichung Taiwan l Hosp, Dept Urol, Taichung, Taiwan China Med Coll Hosp, Dept Obstet & Gynaecol, Taichung, Taiwan China Med Coll Hosp Taichung Taiwan Obstet & Gynaecol, Taichung, Taiwan Natl Tsing Hua Univ, Dept Life Sci, Hsinchu, Taiwan Natl Tsing Hua Univ Hsinchu Taiwan Univ, Dept Life Sci, Hsinchu, Taiwan
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 4, volume: 88, anno: 2001,
pagine: 432 - 436
SICI:
1464-4096(200109)88:4<432:TAOAAO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN-RECEPTOR; SEX-HORMONES; PROSTATE-CANCER; STONE FORMATION; BREAST-CANCER; OXALATE; TESTOSTERONE; RATS; NEPHROLITHIASIS; GROWTH;
Keywords:
androgen receptor; oestrogen receptor; urolithiasis; trinucleotide repeat polymorphism; dinucleotide polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Tsai, FJ China Med Coll Hosp, Dept Med Genet, No 2 Yu Der Rd, Taichung 404, Taiwan China Med Coll Hosp No 2 Yu Der Rd Taichung Taiwan 404 4, Taiwan
Citazione:
W.C. Chen et al., "The association of androgen- and oestrogen-receptor gene polymorphisms with urolithiasis in men", BJU INT, 88(4), 2001, pp. 432-436

Abstract

Objective To evaluate the association of urolithiasis with polymorphic microsatellite (encoding cytosine, adenine, and guanine, CAG) repeats in the exon I region of the androgen receptor (AR) gene and thymine/adenine (TA) repeats in the oestrogen receptor (ER). Patients and methods Patients with urolithiasis (149) and a group of normal controls (102) were examined and compared. The CAG repeats of the AR geneand TA repeats of the ER gene were detected by polymerase chain reaction. The CAG repeats ranged from 171 bp (10 CAG repeats with 141 bp of amplifiedflanking sequences) to 270 bp (43 CAG repeats). The TA repeats ranged from160 bp to 194 bp. Associations between calcium oxalate stone disease and the CAG repeats in AR gene and TA repeats in ER gene were then evaluated. The results were classified according to sex and peaks in allelic frequency distribution. Results There was a significant difference between the male stone patientsand the normal controls in the distribution of CAG repeats in the AR gene. Both groups showed it high percentage of 21-repeats in the allelic distribution, at 17 (16%) and 20 (37%) in stone patients and normal controls, respectively. The results indicate that 21-CAG repeats might be related to it lower risk of stone formation in men (P < 0.05). In the ER gene, the peak allelic distribution of TA repeats was 14, showing it significant difference between male stone patients and the normal control subjects (P < 0.01). There were no statistical differences between female stone patients and the control subjects in either the AR or the ER gene. Conclusion Urolithiasis among men appears to be associated with AR gene CAG repeat and ER gene TA repeat polymorphisms. whereas there was no significant association among female stone patients. These sex hormone receptors seem to be related to the higher incidence of stone formation among men.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:08:02