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Titolo:
Intrarenal bacillus Calmette-Guerin therapy for carcinoma in situ of the upper urinary tract: long-term follow-up and natural course in cases of failure
Autore:
Okubo, K; Ichioka, K; Terada, N; Matsuta, Y; Yoshimura, K; Arai, Y;
Indirizzi:
Kurashiki Cent Hosp, Dept Urol, Kurashiki, Okayama 7108602, Japan Kurashiki Cent Hosp Kurashiki Okayama Japan 7108602 kayama 7108602, Japan
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 4, volume: 88, anno: 2001,
pagine: 343 - 347
SICI:
1464-4096(200109)88:4<343:IBCTFC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSITIONAL-CELL-CARCINOMA; IN-SITU; RENAL PELVIS; PERFUSION THERAPY; INSITU; INSTILLATION; MANAGEMENT; BLADDER;
Keywords:
carcinoma in situ; upper urinary tract; intrarenal instillation; bacillus Calmette-Guerin; BCG; natural course;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Arai, Y Kurashiki Cent Hosp, Dept Urol, 1-1-1 Miwa, Kurashiki, Okayama 7108602, Japan Kurashiki Cent Hosp 1-1-1 Miwa Kurashiki Okayama Japan 7108602 pan
Citazione:
K. Okubo et al., "Intrarenal bacillus Calmette-Guerin therapy for carcinoma in situ of the upper urinary tract: long-term follow-up and natural course in cases of failure", BJU INT, 88(4), 2001, pp. 343-347

Abstract

Objective To assess the long-term efficacy of intrarenal bacillus Calmette-Guerin (BCG) therapy for the treatment of cytologically diagnosed upper tract carcinoma in situ (CIS) and report the time course in cases of failure. Patients and methods Fourteen renal units in 11 patients cytologically diagnosed as having upper urinary tract (UUT) CIS were treated with intrarenalBCG instillation. The BCG solution was administered by retrograde uretericcatheterization weekly for 6 weeks. Results Seven units were radiologically and cytologically free of disease at a median follow-up of 60 months. Two units which showed an initial response had recurrence with ipsilateral UUT CIS. The remaining five units did not respond to BCG. Of seven units with an initial negative response or recurrent UUT CIS, nephroureterectomy was undertaken in one because of coincidental renal cell carcinoma. In four of the remaining six units, invasive pelvic tumour developed at a mean follow-up of 20.5 months after the final instillation. Computed tomography showed wall thickening of the renal pelvis in two and mass-forming tumour in the renal parenchyma mimicking renal cell carcinoma in two. In three of these four cases. retrograde pyelography did not show typical findings of renal pelvic tumour, e.g. filling defect, infundibular obstruction or stenosis. Conclusions Intrarenal BCG is effective in the treatment of UUT CIS in a long-term follow-up. In cases with a poor response or ipsilateral recurrenceof CIS, there is a high risk of developing invasive tumour. Close follow-up using computed tomography is recommended because of the atypical radiographic findings of such tumours.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 21:58:36