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Titolo:
Universal similarity measure for comparing protein structures
Autore:
Betancourt, MR; Skolnick, J;
Indirizzi:
Donald Danforth Plant Sci Ctr, Lab Computat Genom, Creve Coeur, MO 63141 USA Donald Danforth Plant Sci Ctr Creve Coeur MO USA 63141 oeur, MO 63141 USA
Titolo Testata:
BIOPOLYMERS
fascicolo: 5, volume: 59, anno: 2001,
pagine: 305 - 309
SICI:
0006-3525(20011015)59:5<305:USMFCP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Keywords:
protein structure correlations; relative root mean square distance; universal structure similarity measures; protein folding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Skolnick, J Donald Danforth Plant Sci Ctr, Lab Computat Genom, 893 N Warson Rd, Creve Coeur, MO 63141 USA Donald Danforth Plant Sci Ctr 893 N Warson Rd Creve Coeur MO USA 63141
Citazione:
M.R. Betancourt e J. Skolnick, "Universal similarity measure for comparing protein structures", BIOPOLYMERS, 59(5), 2001, pp. 305-309

Abstract

We introduce a new variant of the root mean square distance (RMSD) for comparing protein structures iv,hose range of values is independent of proteansize. This new, dimensionless measure (relative RMSD, or RRMSD) is zero between identical structures and one between structures that are as globally dissimilar as an average pair of random polypeptides of respective sizes. The RRMSD probability distribution between random polypeptides converges to a universal curve as the chain length increases. The correlation coefficients between aligned random structures are computed as a function of polypeptide size showing taro characteristic lengths of 4.7 and 37 residues. These lengths mark the separation between phases of different structural order between native protein fragments. The implications for threading are discussed. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:26:01