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Titolo:
Glioma models
Autore:
Dai, CK; Holland, EC;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Dept Cell Biol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Neurol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Neurosurg, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
fascicolo: 1, volume: 1551, anno: 2001,
pagine: M19 - M27
SICI:
0304-419X(20010831)1551:1<M19:GM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-RECEPTOR; HUMAN-MALIGNANT GLIOMAS; FIBRILLARY ACIDIC PROTEIN; MYC ONCOGENE EXPRESSION; CELL-CYCLE ARREST; C-MYC; TUMOR-SUPPRESSOR; HUMAN GLIOBLASTOMA; GLIAL TUMORS; DIFFERENTIAL EXPRESSION;
Keywords:
glioma; animal model; transgene; gene targeting; retroviral gene transfer; genetic alterations;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Holland, EC Mem Sloan Kettering Canc Ctr, Dept Cell Biol, 430 E 76th St,RRL Rm917B, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr 430 E 76th St,RRL Rm917B New York NY USA 10021
Citazione:
C.K. Dai e E.C. Holland, "Glioma models", BBA-REV CAN, 1551(1), 2001, pp. M19-M27

Abstract

Gliomas are primary central nervous system tumors that arise from astrocytes, oligodendrocytes or their precursors. Gliomas can be classified into several groups according to their histologic characteristics, the most malignant of the gliomas is glioblastoma multiforme. In contrast to the long-standing and well-defined histopathology, the underlying molecular and genetic bases for gliomas are only just emerging. Many genetic alterations have been identified in human gliomas, however, establishing unequivocal correlation between these genetic alterations and gliomagenesis requires accurate animal models for this disease. Here we are reviewing the existing animal models for gliomas with different strategies and our current knowledge on the important issues about this disease, such as activation of signal transduction pathways, disruption of cell cycle arrest pathways, cell-of-origin of gliomas, and therapeutic strategies. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:55:36