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Titolo:
Evidence for the association of ultraviolet-C and H2O2-induced apoptosis with acid sphingomyelinase activation
Autore:
Komatsu, M; Takahashi, T; Abe, T; Takahashi, I; Ida, H; Takada, G;
Indirizzi:
Akita Univ, Sch Med, Dept Pediat, Akita 0108543, Japan Akita Univ Akita Japan 0108543 ch Med, Dept Pediat, Akita 0108543, Japan Jikei Univ, Sch Med, Dept Pediat, Tokyo, Japan Jikei Univ Tokyo JapanJikei Univ, Sch Med, Dept Pediat, Tokyo, Japan
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
fascicolo: 1, volume: 1533, anno: 2001,
pagine: 47 - 54
SICI:
1388-1981(20010829)1533:1<47:EFTAOU>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIEMANN-PICK DISEASE; STRESS-INDUCED APOPTOSIS; JAPANESE PATIENT; CELL-DEATH; CERAMIDE; IDENTIFICATION; EXPRESSION; GENE;
Keywords:
apoptosis; ultraviolet-C; H2O2; acid sphingomyelinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, T Akita Univ, Sch Med, Dept Pediat, Hondo 1-1-1,Akita Shi, Akita 0108543, Japan Akita Univ Hondo 1-1-1,Akita Shi Akita Japan 0108543 , Japan
Citazione:
M. Komatsu et al., "Evidence for the association of ultraviolet-C and H2O2-induced apoptosis with acid sphingomyelinase activation", BBA-MOL C B, 1533(1), 2001, pp. 47-54

Abstract

Ceramide appears to be a potent second messenger implicated in the regulation of diverse cellular processes such as cell growth and differentiation, gene transcription, ligand binding, and cell death. Environmental stress-induced apoptosis is believed to be associated with the sphingomyelin degradation pathway, which generates ceramide as a second messenger in initiating the apoptosis response. To date, two distinct sphingomyelinases, a lysosomal acid sphingomyelinase (ASM), which is deficient in patients affected withtypes A and B Niemann-Pick disease (NPD), and a neutral, magnesium-dependent sphingomyelinase (NSM), are candidate enzymes which respond to apoptotic. stimulations and cause sphingomyelin hydrolysis and subsequent ceramide generation. Using Epstein-Barr virus (EBV)-transformed lymphoblast cells from type A NPD patient which have defined splicing site mutation in the ASM gene, we showed that ASM-deficient cells were defective in ultraviolet-C (UV-C) and hydrogen peroxide (H2O2) induced apoptosis. As another induction ofapoptosis, we exposed this cell line to serum starvation which influences to p53 expression and leads to apoptosis. There were no differences by the degree of apoptosis between ASM-deficient lymphoblast cells and normal lymphoblast. cells. These results are evidence that ASM plays one of the important roles in apoptosis induction by UV-C and H2O2. (C) 2001 Elsevier Science BY. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:52:37