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Titolo:
Differential sensitivity to the wake-promoting actions of norepinephrine within the medial preoptic area and the substantia innominata
Autore:
Berridge, CW; ONeill, J;
Indirizzi:
Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Psychol, Madison, WI 53706 USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 1, volume: 115, anno: 2001,
pagine: 165 - 174
SICI:
0735-7044(200102)115:1<165:DSTTWA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORADRENERGIC BETA-RECEPTORS; LOCUS COERULEUS NEURONS; SLEEP-WAKEFULNESS; ELECTROENCEPHALOGRAPHIC ACTIVITY; BASAL FOREBRAIN; NUCLEUS BASALIS; ADRENERGIC SYSTEM; SEPTAL REGION; MODULATION; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Berridge, CW Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA Univ Wisconsin 1202 W Johnson St Madison WI USA 53706 706 USA
Citazione:
C.W. Berridge e J. O'Neill, "Differential sensitivity to the wake-promoting actions of norepinephrine within the medial preoptic area and the substantia innominata", BEHAV NEURO, 115(1), 2001, pp. 165-174

Abstract

Mapping studies were conducted to delineate the site(s) of action for the arousal-enhancing actions of norepinephrine (NE) within the basal forebrainregion encompassing the medial preoptic area (MPOA) and the substantia innominata (SI). Varying doses of NE, the beta -agonist, isoproterenol, or thealpha (1)-agonist, phenylephrine, were infused into the MPOA or SI in the resting rat. Infusions of NE (4 nmol, 16 nmol/150 nl), isoproterenol (15 nmol/150 nl), and phenylephrine (40 nmol/250 nl) into the MPOA elicited robust increases in waking. In contrast, neither isoproterenol or phenylephrine infusions into the SI altered behavioral state. NE infusions into the SI increased waking only at the highest dose, and at this dose there was an anatomical gradient for NE-induced waking, with infusions placed farther from the MPOA, producing smaller increases in waking. Thus, in contrast to the MPOA, the SI is relatively insensitive to the wake-promoting actions of NE.

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Documento generato il 02/04/20 alle ore 12:13:08