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Titolo:
Comparison of the effects of infant handling, isolation, and nonhandling on acoustic startle, prepulse inhibition, locomotion, and HPA activity in the adult rat
Autore:
Pryce, CR; Bettschen, D; Bahr, NI; Feldon, J;
Indirizzi:
Swiss Fed Inst Technol, Behav Neurobiol Lab, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 1, volume: 115, anno: 2001,
pagine: 71 - 83
SICI:
0735-7044(200102)115:1<71:COTEOI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED CORTICOSTERONE SECRETION; STRESSFUL LIFE EVENT; MATERNAL-DEPRIVATION; LATENT INHIBITION; NUCLEUS-ACCUMBENS; SOCIAL-ISOLATION; NEUROPSYCHIATRIC DISORDERS; INCREASED SENSITIVITY; BEHAVIORAL-RESPONSES; ATTENTIONAL DEFICIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Pryce, CR Swiss Fed Inst Technol, Behav Neurobiol Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
C.R. Pryce et al., "Comparison of the effects of infant handling, isolation, and nonhandling on acoustic startle, prepulse inhibition, locomotion, and HPA activity in the adult rat", BEHAV NEURO, 115(1), 2001, pp. 71-83

Abstract

This study examined whether early isolation (EI), early handling (EH), or early nonhandling (NH) in infant rats alters (a) prepulse inhibition (PPI) of the acoustic startle response (ASR) or its disruption by apomorphine. (b) motor activity or its stimulation by amphetamine, or (c) corticosterone activity (because of its modulation of dopamine activity), in adulthood and in comparison with a normal-husbandry postnatal control environment. EI didnot affect PPI, reduced PPI disruption by apomorphine in males, and increased amphetamine-stimulated activity in males. NH increased the ASR, reducedactivity in the open field, and increased corticosterone reactivity in males. In all paradigms, the effects of EH were similar to those of the control environment. This study provides an important contribution to the evidence on the relationship between postnatal experience and long-term neurobehavioral development in the rat and the relevance of this approach to animal models of neuropsychiatric disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:37:35