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Titolo:
Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: Locomotion, cocaine self-administration, and prepulse inhibition of startle
Autore:
Caine, SB; Humby, T; Robbins, TW; Everitt, BJ;
Indirizzi:
Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 4, volume: 115, anno: 2001,
pagine: 880 - 894
SICI:
0735-7044(200108)115:4<880:BEOPSI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS CORE; HIPPOCAMPAL DAMAGE; ACOUSTIC STARTLE; D-AMPHETAMINE; ELECTROLYTIC LESIONS; EXCITOTOXIC LESIONS; DOPAMINE INFUSION; BASAL GANGLIA; SENSORIMOTOR; APOMORPHINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Everitt, BJ Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England Univ Cambridge Downing St Cambridge England CB2 3EB , England
Citazione:
S.B. Caine et al., "Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: Locomotion, cocaine self-administration, and prepulse inhibition of startle", BEHAV NEURO, 115(4), 2001, pp. 880-894

Abstract

Compelling evidence suggests a primary role for the mesoaccumbens dopaminergic pathway in the behavioral effects of amphetamine and cocaine. but the roles of other projections to the accumbens, including those arising in thehippocampal formation, are less clear. The authors evaluated the effects of discrete excitotoxic lesions of either the dorsal or ventral subiculum onthe locomotor activating. reinforcing, and sensorimotor gating-disruptive effects of psychomotor stimulant drugs. Whereas dorsal subiculum-lesioned rats were hyperactive in tests of exploratory locomotion and startle reactivity. ventral subiculum-lesioned rats exhibited an attenuated locomotor response to amphetamine, moderately impaired acquisition of cocaine self-administration, and reduced levels of prepulse inhibition of startle. These 2 behavioral profiles overlap considerably with those previously observed in rats with lesions of the rostrodorsal and caudomedial accumbens, respectively,and suggest that projections from dorsal subiculum to accumbens core and ventral subiculum to accumbens shell exert distinct influences on behavioralresponses that are amplified by psychomotor stimulant drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:27:59