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Titolo:
Autoimmune aspects of vitiligo
Autore:
Kemp, EH; Waterman, EA; Weetman, AP;
Indirizzi:
Univ Sheffield, No Gen Hosp, Div Clin Sci, Sheffield S5 7AU, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S5 7AU S Yorkshire, England
Titolo Testata:
AUTOIMMUNITY
fascicolo: 1, volume: 34, anno: 2001,
pagine: 65 - 77
SICI:
0891-6934(2001)34:1<65:AAOV>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL SUBSET; MELANOMA-ASSOCIATED HYPOPIGMENTATION; INTERCELLULAR-ADHESION MOLECULE-1; TUMOR-INFILTRATING LYMPHOCYTES; SOLUBLE INTERLEUKIN-2 RECEPTOR; TYROSINASE-RELATED PROTEIN-1; CTLA-4 GENE POLYMORPHISM; SMYTH LINE CHICKENS; HLA-DR ANTIGENS; HUMAN MELANOCYTES;
Keywords:
autoantibody; autoantigen; autoimmunity; T cell; vitiligo;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
138
Recensione:
Indirizzi per estratti:
Indirizzo: Kemp, EH Univ Sheffield, No Gen Hosp, Div Clin Sci, Sheffield S5 7AU, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S5 7AU ire, England
Citazione:
E.H. Kemp et al., "Autoimmune aspects of vitiligo", AUTOIMMUN, 34(1), 2001, pp. 65-77

Abstract

Vitiligo is a depigmenting disorder characterised by the loss of melanocytes from the cutaneous epidermis. Although the exact cause of the condition remains to be established, an autoimmune aetiology has been suggested and several observations support this theory. These will be the topic of discussion in this review. In brief, the disease is frequently associated with other disorders which have an autoimmune origin such as autoimmune thyroiditisand insulin-dependent diabetes mellitus. Furthermore, circulating antibodies and T lymphocytes which react against melanocyte antigens are present inthe sera of a significant proportion of vitiligo patients compared with healthy individuals. Immunosuppressive therapies which are reasonably effective in treating the condition, well-studied animal models of the disease as well as the association of vitiligo with MHC antigens, all add credence to the hypothesis that immune mechanisms play a role in the development of vitiligo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 11:11:53