Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Protection of N-methyl-N '-nitro-N-nitrosoguanidine-induced in vivo clastogenicity by aqueous garlic extract
Autore:
Arivazhagan, S; Nagini, S; Santhiya, ST; Ramesh, A;
Indirizzi:
Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India Univ Madras, Postgrad Inst Basic Med Sci, Dept Genet, Chennai 600113, Tamil Nadu, India Univ Madras Chennai Tamil Nadu India 600113 nai 600113, Tamil Nadu, India
Titolo Testata:
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
fascicolo: 3, volume: 10, anno: 2001,
pagine: 238 - 241
SICI:
0964-7058(2001)10:3<238:PON'IV>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-NITROSO COMPOUNDS; NEEM LEAF EXTRACTS; GASTRIC CARCINOGENESIS; WISTAR RATS; SODIUM-CHLORIDE; STOMACH; INHIBITION; MNNG; ABERRATIONS; INVIVO;
Keywords:
chemoprevention; chromosomal aberrations; clastogen; garlic; gastric cancer; India; micronuclei; N-methyl-N '-nitro-N-nitrosoguanidine (MNNG);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Nagini, S Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 du, India
Citazione:
S. Arivazhagan et al., "Protection of N-methyl-N '-nitro-N-nitrosoguanidine-induced in vivo clastogenicity by aqueous garlic extract", ASIA P J CL, 10(3), 2001, pp. 238-241

Abstract

The modulatory effects of garlic extract on the in vivo clastogenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a carcinogenic nitrosamine, were evaluated by quantification of micronuclei and chromosomal aberrations in metaphase cells from the bone marrow of male Wistar rats. A single intraperitoneal injection of MNNG (40 mg/kg bodyweight) was found to be clastogenic as revealed by the increased frequency of micronucleated polychromatic erythrocytes and chromosomal aberrations. Pretreatment with aqueous garlic extract (250 mg/kg bodyweight) for 5 days significantly reduced the frequencies of MNNG-induced micronuclei and chromosomal aberrations. The results demonstrate that administration of garlic extract protects against the clastogenic effects of MNNG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:30:48