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Titolo:
Histologic analysis of the implanted cartilage in an exact-fit osteochondral transplantation model
Autore:
Makino, T; Fujioka, H; Kurosaka, M; Matsui, N; Yoshihara, H; Tsunoda, M; Mizuno, K;
Indirizzi:
Kobe Univ, Grad Sch Med, Dept Orthopaed Surg, Kobe, Hyogo, Japan Kobe Univ Kobe Hyogo Japan Med, Dept Orthopaed Surg, Kobe, Hyogo, Japan
Titolo Testata:
ARTHROSCOPY
fascicolo: 7, volume: 17, anno: 2001,
pagine: 747 - 751
SICI:
0749-8063(200109)17:7<747:HAOTIC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
KNEE; DEFECTS;
Keywords:
cartilage repair; autogenous osteochondral transplantation; histology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Fujioka, H 7-5-1 Kusunoki Cho,Chuo Ku, Kobe, Hyogo 6500017, Japan 7-5-1 Kusunoki Cho,Chuo Ku Kobe Hyogo Japan 6500017 017, Japan
Citazione:
T. Makino et al., "Histologic analysis of the implanted cartilage in an exact-fit osteochondral transplantation model", ARTHROSCOPY, 17(7), 2001, pp. 747-751

Abstract

Purpose: Osteochondral transplantation is one of the useful treatments forarticular cartilage defect. However, the histologic change of the implanted cartilage has not been reported in detail. We investigated the histology of exact-fit osteochondral transplants used to repair articular cartilage defects in an animal model. Type of Study: This was a nonrandomized control study using an animal model. Methods: Sixteen skeletally mature female Japanese white rabbits were used in the study. The region of the femoral groovewas selected as the site for the osteochondral defect. A full-thickness cylindrical defect (7 mm in diameter and 7 mm in depth) through the articularcartilage and into the subchondral bone was made using the Osteochondral Autograft Transfer System (Arthrex, Naples, FL). The entire osteochondral fragment was removed and then returned to its original site in the femoral condyle precisely. Thus, the defect was repaired with an autogenous osteochondral transplantation of exactly the same size and configuration as the defect. Specimens were obtained 2, 4, 12, and 24 weeks postoperatively and wereanalyzed both macroscopically and histologically. Results: Macroscopically, there was smooth continuity of the articular surface and the integration of the graft to the normal host cartilage. However, histologic examination showed that the layer of the grafted cartilage was thicker than that of thenormal host cartilage and the extracellular matrix of the implanted cartilage exhibited a stronger staining pattern with safranin-O fast green than the normal cartilage. Cell density was higher in the grafted cartilage, particularly in the middle and the deep zones. Round and polygonal hypertrophicclusters of chondrocytes were observed in the middle and deep zones of thegrafted cartilage. Conclusions: The histologic properties of the exact-fitimplanted cartilage were different from that of normal articular cartilage. Further investigation of mechanical and structural properties of grafted cartilage is necessary to verify the long-term effects of osteochondral transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:44:08