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Titolo:
Differential expression of ras signal transduction mediators in verrucous and squamous cell carcinomas of the upper aerodigestive tract
Autore:
Lessard, JL; Robinson, RA; Hoffman, HT;
Indirizzi:
Univ Iowa, Dept Pathol, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 wa, Dept Pathol, Iowa City, IA 52242 USA Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA UnivIowa Iowa City IA USA 52242 ead & Neck Surg, Iowa City, IA 52242 USA
Titolo Testata:
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
fascicolo: 9, volume: 125, anno: 2001,
pagine: 1200 - 1203
SICI:
0003-9985(200109)125:9<1200:DEORST>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASES; INCREASING COMPLEXITY; P53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Robinson, RA Univ Iowa, Dept Pathol, 5232 RCP,200 Hawkins Dr, Iowa City, IA 52242 USA Univ Iowa 5232 RCP,200 Hawkins Dr Iowa City IA USA 52242 USA
Citazione:
J.L. Lessard et al., "Differential expression of ras signal transduction mediators in verrucous and squamous cell carcinomas of the upper aerodigestive tract", ARCH PATH L, 125(9), 2001, pp. 1200-1203

Abstract

Context-ras gene mutations and expression of its gene product have been described in verrucous and squamous cell carcinomas. Other downstream signal-transduction mediators, extracellular signal-regulated kinases 1 and 2 (ERK-1 and ERK-2) and Raf-1, have not yet been as extensively studied. Objective.-To determine patterns of expression of ERK-1, ERK-2, and Raf-1 in verrucous and squamous cell carcinomas of the upper aerodigestive tract. Design.-Seventeen verrucous carcinomas and 10 squamous cell carcinomas of the upper aerodigestive tract were examined for the immunohistochemical expression of ERK-1, ERK-2, and Raf-1 product. Results.-Raf-1 expression was intensely expressed in the most basal portions of the epithelium in verrucous carcinomas, but was minimally expressed in the suprabasalar areas. Anti-Raf-1 staining of the squamous cell carcinomas was diffuse and patchy throughout the tumor cells and was weak in intensity. There was no geographic preference of staining. The cytoplasmic expression of both ERK-1 and ERK-2 was predominantly negative in the most basal layers of the epithelium in the verrucous carcinomas, but was positive in the suprabasalar region of the epithelium. Immunohistochemical expression of ERK-1 and ERK-2 in the squamous carcinomas was diffuse throughout the tumor. Conclusion.-There is strong correlation of the geographic expression of these mediators of ras signal transduction in verrucous and squamous carcinomas, but the cause of these differences remains unclear at present. The expression of these mediator proteins may have potential for diagnosis, as wellas in understanding the biologic behavior of these lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 20:53:45