Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Lysozyme expression by breast carcinomas, correlation with clinicopathologic parameters, and prognostic significance
Autore:
Vizoso, F; Plaza, E; Vazquez, J; Serra, C; Lamelas, ML; Gonzalez, LO; Merino, AM; Mendez, J;
Indirizzi:
Hosp Jove, Serv Cirugia Gen, Gijon 33290, Spain Hosp Jove Gijon Spain 33290 p Jove, Serv Cirugia Gen, Gijon 33290, Spain Hosp Jove, Serv Anestesia, Gijon, Spain Hosp Jove Gijon SpainHosp Jove, Serv Anestesia, Gijon, Spain Hosp Jove, Serv Ginecol, Gijon, Spain Hosp Jove Gijon SpainHosp Jove, Serv Ginecol, Gijon, Spain Hosp Jove, Serv Anat Patol, Gijon, Spain Hosp Jove Gijon SpainHosp Jove, Serv Anat Patol, Gijon, Spain Hosp Virgen de los Lirios de Alcoy, Serv Cirugia Gen, Alicante, Spain HospVirgen de los Lirios de Alcoy Alicante Spain Gen, Alicante, Spain Hosp Cabuenes, Serv Anat Patol, Gijon, Spain Hosp Cabuenes Gijon SpainHosp Cabuenes, Serv Anat Patol, Gijon, Spain Hosp Basurto, Serv Cirugia Gen B, Bilbao, Spain Hosp Basurto Bilbao Spain sp Basurto, Serv Cirugia Gen B, Bilbao, Spain
Titolo Testata:
ANNALS OF SURGICAL ONCOLOGY
fascicolo: 8, volume: 8, anno: 2001,
pagine: 667 - 674
SICI:
1068-9265(200109)8:8<667:LEBBCC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLACTIN RECEPTORS; PROTEIN-COMPOSITION; NONLACTATING WOMEN; CANCER; SECRETIONS; LOCALIZATION; GCDFP-15; TUMORS; FLUID; GENE;
Keywords:
lysozyme; breast cancer; prognosis; prolactin receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Vizoso, F Hosp Jove, Serv Cirugia Gen, Avda Eduardo Castro S-N, Gijon 33290, Spain Hosp Jove Avda Eduardo Castro S-N Gijon Spain 33290 3290, Spain
Citazione:
F. Vizoso et al., "Lysozyme expression by breast carcinomas, correlation with clinicopathologic parameters, and prognostic significance", ANN SURG O, 8(8), 2001, pp. 667-674

Abstract

Background: Here we evaluate the expression and prognostic value of lysozyme, a milk protein that is also synthesized by a significant percentage of breast carcinomas, in women with breast cancer. Methods: Lysozyme expression was examined by immunohistochemical methods in a series of 177 breast cancer tissue sections. Staining was quantified byusing the HSCORE system, which considers both the intensity and the percentage of cells staining at each intensity. The prognostic value of lysozyme was retrospectively evaluated by multivariate analysis that took into account conventional prognostic factors. Results: A total of 126 of 177 carcinomas (69.4%) stained positive for this protein, but there were clear differences among them with regard to the intensity and percentage of stained cells. Lysozyme values were higher in well-differentiated and moderately differentiated tumors than in poorly differentiated tumors (P < .05). Similarly, lysozyme levels were higher in smalland node-negative tumors than in large and node-positive tumors (P < .05). Moreover, results indicated that low lysozyme content predicted shorter relapse-free survival and overall survival (P < .005). Separate Cox multivariate analysis in subgroups of patients as defined by node status showed thatlysozyme expression was an independent prognostic factor able to predict both relapse-free survival and overall survival in node-negative patients (P< .05). Conclusions: Tumoral expression of lysozyme is associated with lesions of favorable evolution in breast cancer. This milk protein may be a new prognostic factor in patients with breast cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:21:37