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Titolo:
Does complete, resection of melanoma metastatic to solid intra-abdominal organs improve survival?
Autore:
Wood, TF; DiFronzo, LA; Rose, DM; Haigh, PL; Stern, SL; Wanek, L; Essner, R; Morton, DL;
Indirizzi:
John Wayne Canc Inst, Santa Monica, CA 90404 USA John Wayne Canc Inst Santa Monica CA USA 90404 Santa Monica, CA 90404 USA
Titolo Testata:
ANNALS OF SURGICAL ONCOLOGY
fascicolo: 8, volume: 8, anno: 2001,
pagine: 658 - 662
SICI:
1068-9265(200109)8:8<658:DCROMM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT-MELANOMA; SURGICAL-TREATMENT; GASTROINTESTINAL-TRACT; ADJUVANT IMMUNOTHERAPY; DISTANT METASTASES; ADRENAL-GLAND; SURGERY; MANAGEMENT; VACCINE; LUNG;
Keywords:
metastatic melanoma; hepatic; spleen; adrenal gland; surgical resection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Essner, R John Wayne Canc Inst, 2200 Santa Monica Blvd, Santa Monica, CA 90404 USA John Wayne Canc Inst 2200 Santa Monica Blvd Santa Monica CA USA 90404
Citazione:
T.F. Wood et al., "Does complete, resection of melanoma metastatic to solid intra-abdominal organs improve survival?", ANN SURG O, 8(8), 2001, pp. 658-662

Abstract

Background: Patients with distant melanoma metastases have median survivals of 4 to 8 months. Previous studies have demonstrated improved survival after complete resection of pulmonary and hollow viscus gastrointestinal metastases. We hypothesized that patients with metastatic disease to intra-abdominal solid organs might also benefit from complete surgical resection. Methods: A prospectively acquired database identified patients treated formelanoma metastatic to the liver, pancreas, spleen, adrenal glands, or a combination of these from 1971 to 2000. The primary intervention was complete or incomplete surgical resection of intra-abdominal solid-organ metastases, and the main outcome measure was postoperative overall survival (OS). Disease-free survival (DFS) was a secondary outcome measure. Results:: Sixty patients underwent adrenalectomy, hepatectomy, splenectomy, or pancreatectomy. Median OS was significantly improved after complete versus incomplete resections, but median OS after complete resection was, notsignificantly different for single-site versus synchronous multisite metastases. The 5-year survival in the, group after complete resection was 24%, whereas in the incomplete resection group, there were no 5-year survivors. Median DFS after complete resection was 15 months. Of note, the 2-year DFS after complete resection was 53% for synchronous multi-site metastases versus 26% for single-site metastases. Conclusions: In highly selected patients with melanoma metastatic to intra-abdominal solid organs, aggressive attempts at complete surgical resectionmay improve OS. It is important that the number of metastatic sites does not seem to affect the OS after complete resection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:06:24