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Titolo:
Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension
Autore:
Steinhorn, RH; Albert, G; Swartz, DD; Russell, JA; Levine, CR; Davis, JM;
Indirizzi:
Northwestern Univ, Dept Pediat, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Dept Pediat, Chicago, IL 60611 USA SUNY Buffalo, Dept Pediat & Physiol, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 Pediat & Physiol, Buffalo, NY 14260 USA SUNY Stony Brook, Winthrop Univ Hosp, Dept Pediat, Mineola, NY 11501 USA SUNY Stony Brook Mineola NY USA 11501 Dept Pediat, Mineola, NY 11501 USA SUNY Stony Brook, Winthrop Univ Hosp, CardioPulm Res Inst, Mineola, NY 11501 USA SUNY Stony Brook Mineola NY USA 11501 ulm Res Inst, Mineola, NY 11501 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 5, volume: 164, anno: 2001,
pagine: 834 - 839
SICI:
1073-449X(20010901)164:5<834:RHSDET>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; NEWBORN LAMBS; DUCTUS-ARTERIOSUS; CIRCULATION; BIRTH; PHARMACOKINETICS; THERAPY; SAFETY;
Keywords:
lung; newborn; pulmonary artery; free radical scavengers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Steinhorn, RH Childrens Mem Hosp, Div Neonatol, 2300 Childrens Plaza 45, Chicago, IL 60614 USA Childrens Mem Hosp 2300 Childrens Plaza 45 Chicago IL USA 60614
Citazione:
R.H. Steinhorn et al., "Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension", AM J R CRIT, 164(5), 2001, pp. 834-839

Abstract

We investigated the pulmonary vascular effects of superoxide dismutase (SOD) alone and in combination with inhaled nitric oxide (iNO) in newborn lambs with persistent pulmonary hypertension (PPHN) following prenatal ligationof the ductus arteriosus. In in vitro experiments, pretreatment with SOD significantly enhanced vascular relaxation in response to the NO donor S-nitrosyl-acetylpenicillamine (SNAP) in fifth-generation pulmonary arteries isolated from lambs with PPHN. In vivo treatment of fully instrumented newbornlambs with a single intratracheal dose of recombinant human CuZn SOD (rhSOD; 5 mg/kg) produced selective dilation of the pulmonary circulation. Further studies, of the combination of rhSOD and iNO, showed enhancement of the pulmonary vascular effects of iNO after brief periods of inhalation of 5 ppm and 80 ppm NO. We conclude that rhSOD reduces pulmonary vascular resistance and facilitates the action of iNO in a lamb model of PPHN. This suggeststhat rhSOD may prove to be an effective adjunctive treatment for newborns with PPHN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:43:39