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Titolo:
Cardiac autonomic control in obstructive sleep apnea - Effects of long-term CPAP therapy
Autore:
Khoo, MCK; Belozeroff, V; Berry, RB; Sassoon, CSH;
Indirizzi:
Univ So Calif, Dept Biomed Engn, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 ed Engn, Los Angeles, CA 90089 USA Univ Florida, Dept Med, Gainesville, FL USA Univ Florida Gainesville FL USA v Florida, Dept Med, Gainesville, FL USA Univ Calif Irvine, VA Med Ctr, Dept Med, Long Beach, CA USA Univ Calif Irvine Long Beach CA USA ed Ctr, Dept Med, Long Beach, CA USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 5, volume: 164, anno: 2001,
pagine: 807 - 812
SICI:
1073-449X(20010901)164:5<807:CACIOS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITIVE AIRWAY PRESSURE; HEART-RATE-VARIABILITY; SYMPATHETIC ACTIVITY; SPECTRAL-ANALYSIS; BLOOD-PRESSURE; DISEASE; INDEXES;
Keywords:
heart rate variability; autonomic nervous system; spectral analysis; sleep-disordered breathing; cardiovascular control;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Khoo, MCK Univ So Calif, Dept Biomed Engn, OHE-500, Los Angeles, CA 90089 USA Univ So Calif OHE-500 Los Angeles CA USA 90089 les, CA 90089 USA
Citazione:
M.C.K. Khoo et al., "Cardiac autonomic control in obstructive sleep apnea - Effects of long-term CPAP therapy", AM J R CRIT, 164(5), 2001, pp. 807-812

Abstract

To determine how long-term treatment with continuous positive airway pressure (CPAP) affects cardiac autonomic function, we measured R-R interval (RRI), respiration, and blood pressure in 13 awake patients with moderate-to-severe obstructive sleep apnea (OSA) in both supine and standing postures, before and after 3 to 9 mo of home therapy. Using visual feedback, the subjects controlled their respiration to track a randomized breathing pattern. From the RRI spectrum, we computed high-frequency power and the ratio of low-frequency to high-frequency power (LHR). To correct for differences in breathing, the average transfer gain relating respiration to RRI changes (G(RSA)) and the modified low-frequency to high-frequency ratio (MLHR) were alsoderived. CPAP therapy did not change the conventional spectral indices of heart rate variability (HRV). However, G(RSA) increased with average nightly CPAP use in supine (p < 0.01) and standing (p < 0.03) postures whereas MLHR decreased with CPAP compliance during standing ( < 0.03). Supine mean heart rate decreased with compliance (p < 0.03). None of the estimated parameters was correlated with duration of therapy when actual CPAP use was not taken into account. These results suggest that CPAP treatment improves vagalheart rate control in patients with OSA and that the degree of improvementvaries directly with compliance level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 05:57:35