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Titolo:
Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease
Autore:
ODonnell, DE; Revill, SM; Webb, KA;
Indirizzi:
Queens Univ, Dept Med, Resp Invest Unit, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 Unit, Kingston, ON K7L 3N6, Canada
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 5, volume: 164, anno: 2001,
pagine: 770 - 777
SICI:
1073-449X(20010901)164:5<770:DHAEII>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPIRATORY FLOW LIMITATION; LUNG-DISEASE; EXERTIONAL BREATHLESSNESS; INSPIRATORY CAPACITY; QUALITATIVE ASPECTS; RESPIRATORY MUSCLE; COPD; MECHANICS; TOLERANCE; ENDURANCE;
Keywords:
COPD; exercise; inspiratory capacity; dynamic lung hyperinflation; emphysema; dyspnea;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: O'Donnell, DE Kingston Gen Hosp, Richardson House,102 Stuart St, Kingston,ON K7L 2V7, Canada Kingston Gen Hosp Richardson House,102 Stuart St Kingston ON Canada K7L 2V7
Citazione:
D.E. O'Donnell et al., "Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease", AM J R CRIT, 164(5), 2001, pp. 770-777

Abstract

The role of dynamic hyperinflation (DH) in exercise limitation in chronic obstructive pulmonary disease (COPD) remains to be defined. We examined DH during exercise in 105 patients with COPD (FEV1 = 37 +/- 13% predicted; mean +/- SID) and studied the relationships between resting lung volumes, DH during exercise, and peak oxygen consumption (Vo(2)). Patients completed pulmonary function tests and incremental cycle exercise tests. We measured thechange in inspiratory capacity (Delta IC) during exercise to reflect changes in DH. During exercise, 80% of patients showed significant DH above resting values. IC decreased 0.37 +/- 0.39 L or 14 +/- 15% predicted during exercise (p < 0.0005), but with large variation in range. Delta IC correlated best with resting IC, both expressed %predicted (r = -0.50, p < 0.0005). Peak Vo(2) (%predicted maximum) correlated best with the peak tidal volume attained (V-T standardized as % of predicted vital capacity) (r = 0.68, p < 0.0005), which, in turn, correlated strongly with IC at peak exercise (r = 0.79, p < 0.0005) or at rest (r = 0.75, p < 0.0005). The extent of DH duringexercise in COPD correlated best with resting IC. DH curtailed the V-T response to exercise. This inability to expand V-T in response to increasing metabolic demand contributed importantly to exercise intolerance in COPD.

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Documento generato il 31/03/20 alle ore 21:54:09