Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Collagen IV promotes repair of renal cell physiological functions after toxicant injury
Autore:
Nony, PA; Nowak, G; Schnellmann, RG;
Indirizzi:
Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, Little Rock, AR 72205 USAUniv Arkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA Univ Arkansas Med Sci, Dept Pharmaceut Sci, Little Rock, AR 72205 USA UnivArkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 3, volume: 281, anno: 2001,
pagine: F443 - F453
SICI:
0363-6127(200109)281:3<F443:CIPROR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RABBIT PROXIMAL TUBULE; HUMAN-SKIN FIBROBLASTS; MESSENGER-RNA LEVELS; ASCORBIC-ACID; HUMAN-PLACENTA; HYDROXYLATION; BIOSYNTHESIS; PROCOLLAGEN; MECHANISMS; SECRETION;
Keywords:
cell injury; regeneration; extracellular matrix; collagen synthesis and deposition; prolyl hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Schnellmann, RG Dept Pharmaceut Sci, 280 Calhoun St,POB 250140, Charleston, SC 29425 USA Dept Pharmaceut Sci 280 Calhoun St,POB 250140 Charleston SC USA 29425
Citazione:
P.A. Nony et al., "Collagen IV promotes repair of renal cell physiological functions after toxicant injury", AM J P-REN, 281(3), 2001, pp. F443-F453

Abstract

Collagen IV is found in the renal proximal tubular cell (RPTC) basement membrane and is a mediator of renal development and function. Pharmacologicalconcentrations Of L-ascorbic acid phosphate (AscP) promote the repair of physiological functions in RPTC sublethally injured by S-(1,2-dichlorovinyl)-L-cysteine (DCVC). We hypothesized that AscP promotes RPTC repair by stimulating collagen IV synthesis and/or deposition. RPTC exhibited increased synthesis but decreased deposition of collagen IV after DCVC exposure. In contrast, RPTC cultured in pharmacological concentrations of AscP maintained collagen IV deposition. The activity of prolyl hydroxylase was decreased in RPTC after DCVC injury, an effect that was partially attenuated in injured RPTC cultured in pharmacological concentrations of AscP. The addition of exogenous collagen IV to the culture media of DCVC-injured RPTC promoted the repair of mitochondrial function and Na+-K+-ATPase activity. However, neither collagen I, laminin, nor fibronectin promoted cell repair. These data demonstrate an association between AscP-stimulated deposition of collagen IV and exogenous collagen IV and repair of physiological functions, suggestingthat collagen IV plays a specific role in RPTC repair after sublethal injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 15:11:58