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Titolo:
Treatment of hydroxychloroquine overdose
Autore:
Marquardt, K; Albertson, TE;
Indirizzi:
Univ Calif San Francisco, Davis Med Ctr, Sch Pharm, Sacramento Div,Calif Poison Control Syst,DABAT, Sacramento, CA 95817 USA Univ Calif San Francisco Sacramento CA USA 95817 Sacramento, CA 95817 USA Univ Calif Davis, Sch Med, Div Pulm & Crit Care Med, Sacramento Div,Calif Poison Control Syst, Sacramento, CA 95817 USA Univ Calif Davis Sacramento CA USA 95817 l Syst, Sacramento, CA 95817 USA
Titolo Testata:
AMERICAN JOURNAL OF EMERGENCY MEDICINE
fascicolo: 5, volume: 19, anno: 2001,
pagine: 420 - 424
SICI:
0735-6757(200109)19:5<420:TOHO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHLOROQUINE; DIAZEPAM; CHILD; MANAGEMENT;
Keywords:
hydroxychloroquine; overdose; quinidine effect; hypotension; chloroquine; hypokalemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Marquardt, K Univ Calif San Francisco, Davis Med Ctr, Sch Pharm, Sacramento Div,Calif Poison Control Syst,DABAT, 2315 Stockton Blvd, Sacramento, CA 95817 USA Univ Calif San Francisco 2315 Stockton Blvd Sacramento CA USA 95817
Citazione:
K. Marquardt e T.E. Albertson, "Treatment of hydroxychloroquine overdose", AM J EMER M, 19(5), 2001, pp. 420-424

Abstract

Hydroxychloroquine overdoses are rarely reported with 7 previous cases found in the English medical literature. We report a case and review the literature. A 16-year-old girl ingested a handful of hydroxychloroquine 200mg, 30 minutes before presentation and presented with tachycardia (heart rate 110 beats/min), hypotension (systolic blood pressure 63 mm Hg), central nervous system depression, conduction defects (QRS=0.14 msec), and hypokalemia (K=2.1 meq/L). She was treated with fluid boluses and dopamine, oxygen, and potassium supplementation. Toxicologic tests confirmed the presence of hydroxychloroquine. The patient's hypotension resolved within 4.5 hours, serum potassium stabilized in 24 hours, and tachycardia gradually decreased over 3 days. Although hydroxychloroquine overdoses are very rare, life-threatening hypotension, conduction problems, and hypokalemia can occur within 30 minutes of ingestion. Symptoms are similar to chloroquine and treatment must be implemented quickly and should be modeled after experience with chloroquine overdoses. Treatment modalities need further study, but current recommendations are: (1) diazepam for seizures and sedation; (2) early intubation and mechanical ventilation; (3) epinephrine for treatment of vasodilation and myocardial depression; (4) potassium replacement with close monitoring of levels; (5) charcoal for gastrointestinal decontamination if ingestion occurred within an hour; (6) high dose diazepam for life-threatening symptoms, until more information becomes available. No value was found for serum alkalinization or extracorporeal methods of drug removal. (Am J Emerg Med 2001;19: 420-424. Copyright (C) 2001 by W.B. Saunders Company).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:30:35