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Titolo:
Comparison of amyloid deposits and infiltration of enteric nervous system in the upper with those in the lower gastrointestinal tract in patients with familial amyloidotic polyneuropathy
Autore:
Anan, I; El-salhy, M; Ando, Y; Terazaki, H; Suhr, OB;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Med 1, Kumamoto 860, Japan Kumamoto Univ Kumamoto Japan 860 ch Med, Dept Med 1, Kumamoto 860, Japan Univ Umea Hosp, Dept Med, Gastroenterol Sect, S-90185 Umea, Sweden Univ Umea Hosp Umea Sweden S-90185 troenterol Sect, S-90185 Umea, Sweden
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 3, volume: 102, anno: 2001,
pagine: 227 - 232
SICI:
0001-6322(200109)102:3<227:COADAI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUODENAL ENDOCRINE-CELLS; DYSFUNCTION; LIVER; JAPAN;
Keywords:
amyloid neuropathy, genetics; gastrointestinal system; ganglions; nerves; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Suhr, OB Kumamoto Univ, Sch Med, Dept Med 1, Kumamoto 860, Japan Kumamoto Univ Kumamoto Japan 860 ept Med 1, Kumamoto 860, Japan
Citazione:
I. Anan et al., "Comparison of amyloid deposits and infiltration of enteric nervous system in the upper with those in the lower gastrointestinal tract in patients with familial amyloidotic polyneuropathy", ACT NEUROP, 102(3), 2001, pp. 227-232

Abstract

Gastrointestinal (GI) complications in familial amyloidotic polyneuropathy(FAP) are invariably present during the course of the disease. The aim of this study was to investigate amyloid deposits in the myenteric plexus of the stomach and small intestine in FAP patients and compare the results withthose of the colon. Six FAP patients were included in the study. The myenteric plexus and the number of macrophages (CD68) and blood vessels were immunostained and quantified by computerised image analysis. Double staining for amyloid and nerve elements was used to detect amyloid infiltration in the myenteric plexus. Amyloid was found predominantly in the walls of blood vessels, and was detected in the nerves of five FAP patients and in 18% of the examined ganglia of the myenteric plexus of the stomach. In the small intestine, 6% of examined ganglia showed amyloid deposits. In contrast, no deposits were found in the myenteric plexus of the colon. CD68-positive cellsshowed no difference in three parts of the GI tract. Most amyloid depositswere noted in the stomach, followed by the small intestine. There are significantly more blood vessels in the stomach and small intestine compared with the colon, and the amount of amyloid correlated with the number of bloodvessels, and not with the amount of nerves and ganglia. The enteric nerve system is not a targeted organ for amyloid deposition in FAP.

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Documento generato il 26/09/20 alle ore 01:38:03