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Titolo:
Thrombospondins and tumor angiogenesis
Autore:
de Fraipont, F; Nicholson, AC; Feige, JJ; Van Meir, EG;
Indirizzi:
Emory Univ, Dept Neurosurg, Mol Neurooncol Lab, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Mol Neurooncol Lab, Atlanta, GA 30322 USA Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Winship Canc Inst, Atlanta, GA 30322 USA CEA, Dept Mol & Struct Biol, INSERM, EMI 0105, Grenoble, France CEA Grenoble France l & Struct Biol, INSERM, EMI 0105, Grenoble, France
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 9, volume: 7, anno: 2001,
pagine: 401 - 407
SICI:
1471-4914(200109)7:9<401:TATA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; MESSENGER-RNA EXPRESSION; NEOPLASTIC HUMAN BREAST; PROMOTES ANGIOGENESIS; COLORECTAL-CARCINOMA; GLIOBLASTOMA CELLS; MURINE DEVELOPMENT; VASCULAR DENSITY; SUPPRESSOR GENE; P53 ALTERATIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Van Meir, EG Emory Univ, Dept Neurosurg, Mol Neurooncol Lab, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 l Lab, Atlanta, GA 30322 USA
Citazione:
F. de Fraipont et al., "Thrombospondins and tumor angiogenesis", TRENDS MO M, 7(9), 2001, pp. 401-407

Abstract

The thrombospondins (TSPs) are a family of five secreted proteins that arewidely distributed in the extracellular matrix of numerous tissues. TSPs are multimodular and each domain specifies a distinct biological function through interaction with a specific receptor. TSP1 and TSP2 have anti-angiogenic activity, which, at least for TSP1, involves interaction with the microvascular endothelial cell receptor CD36. Expression of TSP1 and TSP2 is modulated by hypoxia and by oncogenes. In several tumors (thyroid, colon, bladder carcinomas), TSP1 expression is inversely correlated with tumor grade and survival rate, whereas in others (e.g. breast carcinomas), it is correlated with the stromal response and is of little prognostic value. Recent studies suggest that TSPs or TSP-derived peptides retaining biological activity could be developed into promising new therapeutic strategies for the anti-angiogenic treatment of solid tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 18:52:11