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Titolo:
Evidence for a role of phospholipid oxidation products in atherogenesis
Autore:
Berliner, JA; Subbanagounder, G; Leitinger, N; Watson, AD; Vora, D;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Med Ctr, Dept Pathol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Vienna, Dept Vasc Biol & Thrombosis Res, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 Thrombosis Res, A-1010 Vienna, Austria
Titolo Testata:
TRENDS IN CARDIOVASCULAR MEDICINE
fascicolo: 3-4, volume: 11, anno: 2001,
pagine: 142 - 147
SICI:
1050-1738(200104/05)11:3-4<142:EFAROP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; HUMAN ATHEROSCLEROTIC LESIONS; SMOOTH-MUSCLE CELLS; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; MONOCYTE-DERIVED MACROPHAGES; OXIDIZED PHOSPHOLIPIDS; ENDOTHELIAL-CELLS; LYSOPHOSPHATIDIC ACID; IN-VITRO; STRUCTURAL IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Berliner, JA Univ Calif Los Angeles, Sch Med, Med Ctr, Dept Pathol, Box 981732, Los Angeles, CA 90095 USA Univ Calif Los Angeles Box 981732 Los Angeles CA USA 90095 SA
Citazione:
J.A. Berliner et al., "Evidence for a role of phospholipid oxidation products in atherogenesis", TREND CARD, 11(3-4), 2001, pp. 142-147

Abstract

There is growing evidence for the accumulation of phospholipid oxidation products (some of which can also be formed enzymatically) in several chronicdisease processes including atherosclerosis. There also is considerable evidence that enzymes involved in hydrolysis of these phospholipids (present in both lipoproteins and cells) may be important in regulation of atherogenesis. In vitro studies suggest that these lipids can activate vascular it wall cells to states that contribute to the atherosclerotic process. This review, focuses on two types of bioactive phospholipids: phosphatidyl cholines in which the sn-2 fatty acid has been modified by oxidation and lysophosphatidic acid in it which both the sn-2 and sn-3 positions have been modified. The mechanism by which these phospholipid oxidation products activate cells has revealed the presence of several different receptors and signal transduction pathways. (C) 2001, Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:38:26