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Titolo:
Late endosomes: Sorting and partitioning in multivesicular bodies
Autore:
Piper, RC; Luzio, JP;
Indirizzi:
Univ Cambridge, Dept Clin Biochem, Addenbrookes Hosp, Cambridge CB2 2XY, England Univ Cambridge Cambridge England CB2 2XY osp, Cambridge CB2 2XY, England Univ Cambridge, Cambridge Inst Med Res, Addenbrookes Hosp, Cambridge CB2 2XY, England Univ Cambridge Cambridge England CB2 2XY osp, Cambridge CB2 2XY, England Univ Iowa, Dept Physiol & Biophys, Iowa City, IA 52242 USA Univ Iowa IowaCity IA USA 52242 ysiol & Biophys, Iowa City, IA 52242 USA
Titolo Testata:
TRAFFIC
fascicolo: 9, volume: 2, anno: 2001,
pagine: 612 - 621
SICI:
1398-9219(200109)2:9<612:LESAPI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANNOSE 6-PHOSPHATE RECEPTOR; GROWTH-FACTOR RECEPTOR; SACCHAROMYCES-CEREVISIAE; MEMBRANE-PROTEINS; ENDOCYTIC PATHWAY; EGF RECEPTOR; PRELYSOSOMAL COMPARTMENT; TYROSINE PHOSPHORYLATION; PREVACUOLAR COMPARTMENT; MEDIATED ENDOCYTOSIS;
Keywords:
degradation; endocytosis; endosome; lysosome; multivesicular body; ubiquitin; vacuole; vesicle budding;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Luzio, JP Univ Cambridge, Dept Clin Biochem, Addenbrookes Hosp, Hills Rd, Cambridge CB2 2XY, England Univ Cambridge Hills Rd Cambridge England CB2 2XY 2XY, England
Citazione:
R.C. Piper e J.P. Luzio, "Late endosomes: Sorting and partitioning in multivesicular bodies", TRAFFIC, 2(9), 2001, pp. 612-621

Abstract

Late endosomes, which have the morphological characteristics of multivesicular bodies, have received relatively little attention in comparison with early endosomes and lysosomes. Recent work in mammalian and yeast cells has given insights into their structure and function, including the generation of their multivesicular morphology. Lipid partitioning to create microdomains enriched in specific lipids is observed in late endosomes, with some lumenal vesicles enriched in lysobisphosphatidic acid and others in phosphatidylinositol 3-phosphate. Sorting of membrane proteins into the lumenal vesicles may occur because of the properties of their trans-membrane domains, oras a result of tagging with ubiquitin. Yeast class E Vps proteins and their mammalian orthologs are the best candidates to make up the protein machinery that controls inward budding, a process that starts in early endosomes. Late endosomes are able to undergo homotypic fusion events and also heterotypic fusion with lysosomes, a process that delivers endocytosed macromolecules for proteolytic degradation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:19:04