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Titolo:
Combined exposure to sarin and pyridostigmine bromide increased levels of rat urinary 3-nitrotyrosine and 8-hydroxy-2 '-deoxyguanosine, biomarkers ofoxidative stress
Autore:
Abu-Qare, AW; Abou-Donia, MB;
Indirizzi:
Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Pharmacol & Canc Biol, Durham, NC 27710 USA
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 1, volume: 123, anno: 2001,
pagine: 51 - 58
SICI:
0378-4274(20010806)123:1<51:CETSAP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-DAMAGE; ACETYLCHOLINE-RECEPTORS; TYROSINE NITRATION; IN-VITRO; PEROXYNITRITE; MICE; BRAIN; ACID; QUANTIFICATION; NITROTYROSINE;
Keywords:
pyridostigmine bromide; sarin; oxidative stress; nerve agents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Abou-Donia, MB Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, POB 3813, Durham, NC 27710USA Duke Univ POB 3813 Durham NC USA 27710 Durham, NC 27710USA
Citazione:
A.W. Abu-Qare e M.B. Abou-Donia, "Combined exposure to sarin and pyridostigmine bromide increased levels of rat urinary 3-nitrotyrosine and 8-hydroxy-2 '-deoxyguanosine, biomarkers ofoxidative stress", TOX LETT, 123(1), 2001, pp. 51-58

Abstract

In this study concentrations of markers of oxidative stress 3-nitrotyrosine and 8-hydroxy-2'-deoxyguanosine (8-OhdG) were determined in rat urine following a single oral dose of pyridostigmine bromide (PB) 13 mg/kg and a single intramuscular dose of sarin 80 mug/kg alone or in combination. Urine samples were collected 16, 24, 48, 72, and 96 It following dosing. Control urine samples of five rats treated with normal saline were also collected at the same time intervals. A combined dose of PB and Sarin significantly increased levels of 3-nitrotyrosine and (8-OhdG) starting 48 It after dosing. An increase in the concentration of these markers was not detected followinga single dose of PB or Sarin alone. Maximal increase in 3-nitrotyrosine and 8-OhdG was detected 48 h after administration of a combination PB and Sarin. The results indicate that concurrent exposure to PB and Sarin could generate free radical species that may cause oxidative stress in rats. The results may have significant impact if veterans were expose to Sarin followingan oral dose of PB. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:24:15