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Titolo:
Observation of the breast cancer patient with a tumor-positive sentinel node: Implications of the ACOSOG Z0011 trial
Autore:
Grube, BJ; Giuliano, AE;
Indirizzi:
St Johns Hlth Ctr, John Wayne Canc Inst, Joyce Eisenberg Keefer Breast Ctr, Santa Monica, CA 90404 USA St Johns Hlth Ctr Santa Monica CA USA 90404 r, Santa Monica, CA 90404 USA
Titolo Testata:
SEMINARS IN SURGICAL ONCOLOGY
fascicolo: 3, volume: 20, anno: 2001,
pagine: 230 - 237
SICI:
8756-0437(200104/05)20:3<230:OOTBCP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CLINICAL-TRIAL; LYMPH-NODE; AXILLARY DISSECTION; CONSERVATIVE SURGERY; RADIATION-THERAPY; GAMMA-PROBE; ADJUVANT CHEMOTHERAPY; PREMENOPAUSAL WOMEN; INITIAL EXPERIENCE; TOTAL MASTECTOMY;
Keywords:
breast cancer; sentinel node; axillary staging; clinical trials;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Giuliano, AE St Johns Hlth Ctr, John Wayne Canc Inst, Joyce Eisenberg Keefer Breast Ctr, 2200 Santa Monica Blvd, Santa Monica, CA 90404 USA St Johns Hlth Ctr 2200 Santa Monica Blvd Santa Monica CA USA 90404
Citazione:
B.J. Grube e A.E. Giuliano, "Observation of the breast cancer patient with a tumor-positive sentinel node: Implications of the ACOSOG Z0011 trial", SEM SURG ON, 20(3), 2001, pp. 230-237

Abstract

Axillary lymph node status has been the most important prognostic factor for breast cancer throughout the past century. During the past decade, intraoperative lymphatic mapping with sentinel lymph node dissection (SLND) has been investigated as an alternative staging modality. This technique may beas accurate as ALND, and certainly is less invasive. Adjuvant treatment recommendations, which historically were made on the basis of lymph node status alone, now take into account primary tumor features, molecular markers, and patient characteristics. This evolution of current treatment patterns is driven in part by the diminishing size of tumors, the simultaneous decrease in the presence of axillary metastases, and a better understanding of tumor-specific risk factors. How do these trends affect the interpretation ofa tumor-positive sentinel node (SN)? Can an axilla with a positive SN be observed? Should it be observed? This review examines the implications of a positive SN in the context of smaller tumor size, decreased nodal disease, and increased reliance on alternative prognostic factors for treatment decisions. The historical data comparing ALND to no ALND in clinically node-negative patients is reviewed and discussed in the context of observation for a positive SN. These are the issues underlying the ACOSOG ZOO10 and ZOO11 trials. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:55:44