Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Clinical features of latent inhibition in schizophrenia
Autore:
Rascle, C; Mazas, O; Vaiva, G; Tournant, M; Raybois, O; Goudemand, M; Thomas, P;
Indirizzi:
Univ Lille 2, Ctr Hosp Reg & Univ Lille, Sch Med, Dept Psychiat, F-59037 Lille, France Univ Lille 2 Lille France F-59037 , Dept Psychiat, F-59037 Lille, France
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 2-3, volume: 51, anno: 2001,
pagine: 149 - 161
SICI:
0920-9964(20010901)51:2-3<149:CFOLII>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRONE NORMAL SUBJECTS; IRRELEVANT STIMULI; ATTENTION DISORDER; COGNITIVE MODEL; HALOPERIDOL; PREEXPOSURE; AMPHETAMINE; DOPAMINE; ABOLITION; DURATION;
Keywords:
inter-species character; latent inhibition; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Rascle, C Univ Lille 2, Ctr Hosp Reg & Univ Lille, Sch Med, Dept Psychiat,6 Rue Pr Laguesse, F-59037 Lille, France Univ Lille 2 6 Rue Pr Laguesse Lille France F-59037 lle, France
Citazione:
C. Rascle et al., "Clinical features of latent inhibition in schizophrenia", SCHIZOPHR R, 51(2-3), 2001, pp. 149-161

Abstract

Paradigms of Latent Inhibition (LI) are inter-species and derived from learning theories. They are considered as tools which allow the attentional processes to be studied. The absence of LI is interpreted as difficulty in discriminating relevant and irrelevant stimuli. Abolition of LI has been shown in acute schizophrenics. The objectives of our study were partly to validate an LI paradigm, based on a contingency detection between two stimuli, in healthy subjects, and partly to analyse LI in schizophrenics. The study included 105 subjects (65 patients and 40 controls). Patients fulfilled the DSM IV diagnosis of schizophrenia. 35 in the acute phase and 30 in the chronic phase. We observed a loss of LI for acute schizophrenics, and an enhancement of LI for chronic schizophrenics. The variations in Ll are interpreted from the perspective of a disturbance in the attentional processes. The LI status in acute schizophrenics appears to correlate with the clinical criteria with a prognostic value (low intensity of the negative dimension, late age at the first hospitalization). Moreover, the enhancement of LI correlates with the negative dimension of schizophrenic disease. This correlationis found in acute and chronic schizophrenics. It suggests that the variations of LI may be an indicator of adaptive strategies to a cognitive dysfunction specific to schizophrenia. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:56:41