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Titolo:
Efficacy and safety profile of cyclosporin A in the treatment of juvenile chronic (idiopathic) arthritis. Results of a 10-year prospective study
Autore:
Gerloni, V; Cimaz, R; Gattinara, M; Arnoldi, C; Pontikaki, I; Fantini, F;
Indirizzi:
Ist Clin Perfezionamento, Dept Paediat, I-20122 Milan, Italy Ist Clin Perfezionamento Milan Italy I-20122 ediat, I-20122 Milan, Italy Univ Milan, Dept Rheumatol, Ctr Rheumat Children, Gaetano Pini Inst, Milan, Italy Univ Milan Milan Italy heumat Children, Gaetano Pini Inst, Milan, Italy
Titolo Testata:
RHEUMATOLOGY
fascicolo: 8, volume: 40, anno: 2001,
pagine: 907 - 913
SICI:
1462-0324(200108)40:8<907:EASPOC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; RHEUMATOID-ARTHRITIS; DOUBLE-BLIND; STILLS-DISEASE; THERAPY; UVEITIS; DERMATOMYOSITIS; RESISTANT; CHILDREN;
Keywords:
cyclosporin; therapy; JCA; children; uveitis; systemic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Cimaz, R Ist Clin Perfezionamento, Dept Paediat, Via Commenda 9, I-20122 Milan, Italy Ist Clin Perfezionamento Via Commenda 9 Milan Italy I-20122 taly
Citazione:
V. Gerloni et al., "Efficacy and safety profile of cyclosporin A in the treatment of juvenile chronic (idiopathic) arthritis. Results of a 10-year prospective study", RHEUMATOLOG, 40(8), 2001, pp. 907-913

Abstract

Objective. This open prospective trial was performed in order to assess the efficacy and safety of cyclosporin A in the treatment of patients with juvenile chronic arthritis (JCA). Methods. Thirty-four of the patients enrolled were affected by systemic-onset disease and seven by chronic anterior uveitis associated with JCA. The cyclosporin dose was usually 3-5 mg/kg per day. The average duration of therapy was 1.4 yr, with a maximum of 7.2 yr. Results. The efficacy of treatment was mainly evident in terms of control of fever and reduction of steroid therapy. The benefits with respect to arthritis, laboratory parameters and uveitis seemed to be less clear-cut. Side-effects were frequent but usually mild or reversible. Sixty-six per cent of the study population withdrew from therapy because of inefficacy or side-effects. Eight systemic patients withdrew from therapy owing to complete remission. Conclusion. Cyclosporin can be used in the treatment of JCA, its main benefits being the control of fever and a steroid-sparing effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:19:29