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Titolo:
Bone density, ultrasound measurements and body composition in early ankylosing spondylitis
Autore:
Toussirot, E; Michel, F; Wendling, D;
Indirizzi:
Univ Besancon, Hosp Jean Minjoz, Dept Rheumatol, F-25030 Besancon, France Univ Besancon Besancon France F-25030 heumatol, F-25030 Besancon, France
Titolo Testata:
RHEUMATOLOGY
fascicolo: 8, volume: 40, anno: 2001,
pagine: 882 - 888
SICI:
1462-0324(200108)40:8<882:BDUMAB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE-ACTIVITY; MINERAL DENSITY; FRACTURES; OSTEOPOROSIS; MASS;
Keywords:
bone mineral density; ultrasound measurements; DEXA; ankylosing spondylitis; body composition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Toussirot, E Univ Besancon, Hosp Jean Minjoz, Dept Rheumatol, Bd A Fleming, F-25030 Besancon, France Univ Besancon Bd A Fleming Besancon France F-25030 n, France
Citazione:
E. Toussirot et al., "Bone density, ultrasound measurements and body composition in early ankylosing spondylitis", RHEUMATOLOG, 40(8), 2001, pp. 882-888

Abstract

Objectives. In this cross-sectional study, we evaluated bone density usingboth dual-energy X-ray absorptiometry (DEXA) and quantitative ultrasound (QUS) techniques and examined the changes in body composition in patients with ankylosing spondylitis (AS). Methods. Seventy-one patients were compared with seventy-one sex- and age-matched controls. Bone mineral density (BMD) was evaluated at the lumbar spine and femoral neck with a Lunar device. Total body measurements were alsoperformed, giving BMD and bone mineral content (BMC) of the whole body, and fat and lean masses. Broadband ultrasound attenuation (BUA), speed of sound and stiffness were measured at the calcaneus using an Achilles ultrasound device. Results. The patients had significantly lower lumbar spine, femoral neck and total body BMD as compared with controls (all P < 0.05). Total body BMC was also decreased in AS (P = 0.002). On the contrary, fat and lean masses did not differ between patients and controls as observed for QUS values. Mild to good correlations were found between BMD and QUS parameters (r ranging from 0.22 to 0.53; all P less than or equal to 0.01). When applying the World Health Organization (WHO) definition for osteoporosis, we found that 46.5% of patients had lumbar spine osteopenia and/or osteoporosis, while 26.8% had femoral neck osteopenia and/or osteoporosis (controls: 23.9 and 10%;P = 0.001 and 0.08, respectively). No relationships between disease activity (as evaluated by erythrocyte sedimentation rate, serum C-reactive protein levels and BASDAI, a clinical index of disease activity) and BMD measurements were found and only femoral neck BMD correlated with disease duration (r = -0.25, P = 0.04). Finally, the presence of talalgia in AS did not influence the QUS values. Conclusion. These results confirm that AS patients have decreased BMD values at both the spine and femur, and also in total body measurements. reflecting a generalized bone loss. On the contrary, soft tissue composition doesnot seem to be influenced by the disease. QUS parameters were found to be similar between patients and controls, suggesting that the QUS method did not provide additive information to DEXA. As it is thought that QUS providesinformation about qualitative properties of bone, the normal results of QUS values in our patient series argue against modifications in AS bone micro-architecture.

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Documento generato il 03/07/20 alle ore 22:35:48