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Titolo:
Th1 and Th2 cytokine responses to academic stress
Autore:
Kang, DH; Fox, C;
Indirizzi:
Univ Alabama, Sch Nursing, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ch Nursing, Birmingham, AL 35294 USA Ohio State Univ, Coll Med, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 v, Coll Med, Columbus, OH 43210 USA
Titolo Testata:
RESEARCH IN NURSING & HEALTH
fascicolo: 4, volume: 24, anno: 2001,
pagine: 245 - 257
SICI:
0160-6891(200108)24:4<245:TATCRT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; KILLER-CELL-ACTIVITY; IMMUNE-RESPONSES; ASTHMATIC ADOLESCENTS; PSYCHOLOGICAL STRESS; INTERLEUKIN-2 PRODUCTION; MEDICAL-STUDENTS; MAJOR DEPRESSION; T-LYMPHOCYTES; OLDER ADULTS;
Keywords:
cytokine; Th1/Th2; academic stress; history of asthma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Kang, DH Univ Alabama, Sch Nursing, 1430 3rd Ave S, Birmingham, AL 35294 USA Univ Alabama 1430 3rd Ave S Birmingham AL USA 35294 AL 35294 USA
Citazione:
D.H. Kang e C. Fox, "Th1 and Th2 cytokine responses to academic stress", RES NURS H, 24(4), 2001, pp. 245-257

Abstract

Predominant Th2 profiles are associated with the worsening of asthma, and stress is speculated to induce a Th2 profile. The goals of this study were to examine the responses of the cytokines Th1 (IFN-gamma and IL-2) and Th2 (IL-4, IL-5, and IL-6) to a stressor and to look at the relationships between cytokine and psychological responses. Twenty-four students with and without a history of asthma completed questionnaires and gave blood samples during nonexam and exam periods. Cytokines were measured by ELISA from supernatants of stimulated mononuclear cells (MNC) and whole blood. During examinations, there were a significant decrease in IL-2 and a significant increasein IL-6 Production (both cultures) and a significant decrease in IFN-gammaproduction (MNC cultures). Baseline IL-2 levels showed significant negative correlations with several stress and mood scores. Findings of this study indicate a down-regulation of Th1 and a selective upregulation of Th2 cytokines during a stressful exposure. (C) 2001 John Wiley & Sons, Inc.

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Documento generato il 02/04/20 alle ore 12:35:58