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Titolo:
Windows in early mammary development: critical or not?
Autore:
Knight, CH; Sorensen, A;
Indirizzi:
Hannah Res Inst, Ayr KA6 5HL, Scotland Hannah Res Inst Ayr Scotland KA6 5HL nah Res Inst, Ayr KA6 5HL, Scotland
Titolo Testata:
REPRODUCTION
fascicolo: 3, volume: 122, anno: 2001,
pagine: 337 - 345
SICI:
1470-1626(200109)122:3<337:WIEMDC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; GLAND DEVELOPMENT; TISSUE INTERACTION; EXPOSURE; MILK; GROWTH; MICE; DIETHYLSTILBESTROL; LACTATION; PREGNANCY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Knight, CH Hannah Res Inst, Ayr KA6 5HL, Scotland Hannah Res Inst Ayr Scotland KA6 5HL t, Ayr KA6 5HL, Scotland
Citazione:
C.H. Knight e A. Sorensen, "Windows in early mammary development: critical or not?", REPRODUCT, 122(3), 2001, pp. 337-345

Abstract

Two critical windows in mammary development have been proposed. The first arises from observations in rodents that nutrition during fetal and neonatal periods can affect mammary ductular outgrowth, subsequent proliferative activity and, eventually, tumorigenesis, that is, potentially it could have a long-term effect on pathological outcome (breast cancer) in women. The second similarly involves early diet, but in this case the outcome is phenotypic, in that dairy heifers reared too quickly during the peripubertal period subsequently show impaired udder development and reduced milk yield persisting throughout life. Most mammary development occurs during pregnancy, but this period is usually thought of only in terms of the immediate outcome for the subsequent lactation; it is not believed to be a critical window, at least in terms of lifetime mammary productivity. This review examines theevidence underlying these various claims and attempts to define the mechanisms involved, and also considers whether derangements occurring earlier inlife (prenatally) could also have long-term consequences for physiologicalor pathological mammary development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 11:14:11