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Titolo:
Aromatic di-alanine repeats (AdAR) are structural motifs characteristic ofthe soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) family
Autore:
Bruckert, F; Casavant, T; Satre, M;
Indirizzi:
Univ Grenoble 1, UMR5092 CNRS, EBSI, DBMS,Lab Biochim & Biophys Syst Integres,CEA, F-38054 Grenoble 09, France Univ Grenoble 1 Grenoble France 09 gres,CEA, F-38054 Grenoble 09, France Univ Iowa, Dept Elect & Comp Engn, Parallel Proc Lab, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 rallel Proc Lab, Iowa City, IA 52242 USA Univ Iowa, Coordinated Lab Computat Genomics, Iowa City, IA 52242 USA UnivIowa Iowa City IA USA 52242 mputat Genomics, Iowa City, IA 52242 USA
Titolo Testata:
PROTEINS-STRUCTURE FUNCTION AND GENETICS
fascicolo: 1, volume: 45, anno: 2001,
pagine: 40 - 46
SICI:
0887-3585(20011001)45:1<40:ADR(AS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR MEMBRANE-FUSION; ALPHA-SNAP; CRYSTAL-STRUCTURE; ATPASE ACTIVITY; NSF; IDENTIFICATION; COMPLEX; YEAST; STIMULATION; EXOCYTOSIS;
Keywords:
membrane fusion; alpha-helix; tetratrico peptide repeat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Bruckert, F Univ Grenoble 1, UMR5092 CNRS, EBSI, DBMS,Lab Biochim & Biophys Syst Integres,CEA, 17 Rue Martyrs, F-38054 Grenoble 09, France Univ Grenoble 1 17 Rue Martyrs Grenoble France 09 09, France
Citazione:
F. Bruckert et al., "Aromatic di-alanine repeats (AdAR) are structural motifs characteristic ofthe soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) family", PROTEINS, 45(1), 2001, pp. 40-46

Abstract

The aromatic di-alanine repeat is a novel 12-amino acid-long motif constituting alternate small and large hydrophobic residues that mediate the closepacking of alpha -helices. A hidden Markov model profile was constructed from the motifs initially described in Soluble N-ethyl maleimide-sensitive factor attachment proteins (SNAP), a family of soluble proteins involved in intracellular membrane fusion. Scanning different sets of protein sequencesshowed unambiguously that this profile defines a structural motif independent of the tetratrico peptide repeat, another widespread alpha -helical motif In addition to SNAP, aromatic di-alanine repeats are found in selective LIM homeodomain binding proteins (SLB) and in proteins from the Pyrococcus and Archaeoglobus prokaryotes. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 15:02:58