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Titolo:
The sequence determinants of cadherin molecules
Autore:
Kister, AE; Roytberg, MA; Chothia, C; Vasiliev, JM; Gelfand, IM;
Indirizzi:
Rutgers State Univ, Dept Math, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 Math, Piscataway, NJ 08854 USA Russian Acad Sci, Inst Math Problems Biol, Pushchino 142292, Moscow Region, Russia Russian Acad Sci Pushchino Moscow Region Russia 142292 cow Region, Russia MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC Cambridge England CB2 2QH , Mol Biol Lab, Cambridge CB2 2QH, England Oncol Sci Ctr Russia, Moscow 115478, Russia Oncol Sci Ctr Russia Moscow Russia 115478 Russia, Moscow 115478, Russia
Titolo Testata:
PROTEIN SCIENCE
fascicolo: 9, volume: 10, anno: 2001,
pagine: 1801 - 1810
SICI:
0961-8368(200109)10:9<1801:TSDOCM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULES; STRUCTURAL BASIS; V-H; DIVERSITY; DATABASE; DOMAIN;
Keywords:
classic cadherins; cell adhesion molecules; method for protein family recognition; sequence comparison/classification;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Kister, AE Rutgers State Univ, Dept Math, Piscataway, NJ 08854 USA RutgersState Univ Piscataway NJ USA 08854 taway, NJ 08854 USA
Citazione:
A.E. Kister et al., "The sequence determinants of cadherin molecules", PROTEIN SCI, 10(9), 2001, pp. 1801-1810

Abstract

The sequence and structural analysis of cadherins. allow us to find sequence determinants-a few positions in sequences whose residues are characteristic and specific for the structures of a given family. Comparison of the five extracellular domains of classic cadherins showed that they share the same sequence determinants despite only a nonsignificant sequence similarity between the N-terminal domain and other extracellular domains. This allowedus to predict secondary structures and propose three-dimensional structures for these domains that have not been structurally analyzed previously. A new method of assigning a sequence to its proper protein family is suggested: analysis of sequence determinants. The main advantage of this method is that it is not necessary to know all or almost all residues in a sequence as required for other traditional classification tools such as BLAST, FASTA,and Hmm. Using the key positions only, that is, residues that serve as thesequence determinants, we found that all members of the classic cadherin family were unequivocally selected from among 80,000 examined proteins. In addition, we proposed a model for the secondary structure of the cytoplasmicdomain of cadherins based on the principal relations between sequences andsecondary structure multialignments. The patterns of the secondary structure of this domain can serve as the distinguishing characteristics of cadherins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 08:48:28