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Titolo:
Very large long-term effective population size in the virulent human malaria parasite Plasmodium falciparum
Autore:
Hughes, AL; Verra, F;
Indirizzi:
Univ S Carolina, Dept Biol Sci, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 pt Biol Sci, Columbia, SC 29208 USA Univ Roma La Sapienza, Ist Parassitol, I-00185 Rome, Italy Univ Roma La Sapienza Rome Italy I-00185 Parassitol, I-00185 Rome, Italy
Titolo Testata:
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
fascicolo: 1478, volume: 268, anno: 2001,
pagine: 1855 - 1860
SICI:
0962-8452(20010907)268:1478<1855:VLLEPS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUTATION-RATE VARIES; NUCLEOTIDE SUBSTITUTIONS; SEGREGATING SITES; NATURAL-SELECTION; DNA POLYMORPHISM; RECOMBINATION; OVERDOMINANT; BOTTLENECK; EVOLUTION; SEQUENCES;
Keywords:
effective population size; genetic polymorphism; malaria; Plasmodium falciparum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hughes, AL Univ S Carolina, Dept Biol Sci, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 , Columbia, SC 29208 USA
Citazione:
A.L. Hughes e F. Verra, "Very large long-term effective population size in the virulent human malaria parasite Plasmodium falciparum", P ROY SOC B, 268(1478), 2001, pp. 1855-1860

Abstract

It has been proposed that the virulent human malaria parasite Plasmodium falciparum underwent a recent severe population bottleneck. In order to testthis hypothesis, we estimated the effective population size of this species from the patterns of nucleotide substitution at 23 nuclear protein-codingloci, using a variety of methods based on coalescent theory. Both simple methods and phylogenetically based maximum likelihood methods yielded the conclusion that the effective population size of this species has been of theorder of at least 105 for the past 300 000-400 000 years.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:11:48