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Titolo:
Second-trimester maternal serum alpha-fetoprotein (MSAFP) is elevated in women with adverse pregnancy outcome associated with inherited thrombophilias
Autore:
Ochshorn, Y; Kupferminc, MJ; Eldor, A; Wolman, I; Lessing, JB; Yaron, Y;
Indirizzi:
Tel Aviv Sourasky Med Ctr, Inst Genet, Prenatal Diag Unit, IL-64239 Tel Aviv, Israel Tel Aviv Sourasky Med Ctr Tel Aviv Israel IL-64239 4239 Tel Aviv, Israel Lis Matern Hosp, Dept Obstet & Gynecol, Sourasky Med Ctr, Tel Aviv, IsraelLis Matern Hosp Tel Aviv Israel col, Sourasky Med Ctr, Tel Aviv, Israel Sourasky Med Ctr, Inst Hematol, Tel Aviv, Israel Sourasky Med Ctr Tel Aviv Israel ed Ctr, Inst Hematol, Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel
Titolo Testata:
PRENATAL DIAGNOSIS
fascicolo: 8, volume: 21, anno: 2001,
pagine: 658 - 661
SICI:
0197-3851(200108)21:8<658:SMSA(I>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; PRE-ECLAMPSIA; FETAL GROWTH; MIDTRIMESTER; PREECLAMPSIA; THROMBOSIS; MUTATION;
Keywords:
thrombophilia; alpha-fetoprotein (AFP); human chorionic gonadotrophin (hCG); pregnancy complications;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Yaron, Y Tel Aviv Sourasky Med Ctr, Inst Genet, Prenatal Diag Unit, 6 Weizmann St, IL-64239 Tel Aviv, Israel Tel Aviv Sourasky Med Ctr 6 Weizmann St Tel Aviv Israel IL-64239
Citazione:
Y. Ochshorn et al., "Second-trimester maternal serum alpha-fetoprotein (MSAFP) is elevated in women with adverse pregnancy outcome associated with inherited thrombophilias", PRENAT DIAG, 21(8), 2001, pp. 658-661

Abstract

Obstetric complications, such as severe pre-eclampsia, fetal growth restriction, abruptio placentae, or stillbirth are associated with abnormally elevated second-trimester maternal serum alpha-fetoprotein (MSAFP) and beta subunit of human chorionic gonadotrophin (beta hCG). This has been attributedto placental abnormalities. Women with thrombophilias have been shown to have abnormalities of the placenta resulting in adverse pregnancy outcome inthese patients. The purpose of the present study was to evaluate whether women with pregnancy complications and inherited thrombophilias have abnormally elevated second-trimester MSAFP or beta hCG. Sixty-two women with pregnancy complications were tested for inherited thrombophilias several months after delivery. The thrombophilia group included 29 women with pregnancy complications and an inherited thrombophilia and the control group included 33 other patients without thrombophilia. Patients in the thrombophilia grouphad a higher median MoM MSAFP compared to the controls (1.337 vs 1.086, p=0.0516). The incidence of abnormally elevated MSAFP (>2.5 MoM) was also significantly higher in the thrombophilia group compared to controls (21% vs 3%, p=0.04). Neither the median MoM beta hCG nor the incidence of abnormallyelevated beta hCG were significantly different between the groups. We conclude that second trimester MSAFP, but not beta hCG, is abnormally elevated in patients with thrombophilia and obstetric complications. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:37:17