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Titolo:
Inhalation study on exposure to bitumen fumes: Formation of DNA adducts invarious rat tissues following nose-only inhalation
Autore:
Genevois-Charmeau, C; Binet, S; Bonnet, P; Lafontaine, M; Brandt, H; Kriech, A; De Groot, PC; Wissel, H; Garren, L; Morele, Y; Nunge, H; Castegnaro, M;
Indirizzi:
Int Agcy Res Canc, F-69372 Lyon 08, France Int Agcy Res Canc Lyon France08 Agcy Res Canc, F-69372 Lyon 08, France Inst Natl Rech & Secur, F-54501 Vandoeuvre Les Nancy, France Inst Natl Rech & Secur Vandoeuvre Les Nancy France F-54501 Nancy, France Shell Res & Technol Ctr, NL-1030 BM Amsterdam, Netherlands Shell Res & Technol Ctr Amsterdam Netherlands NL-1030 BM am, Netherlands Heritage Res Grp, Indianapolis, IN 46231 USA Heritage Res Grp Indianapolis IN USA 46231 rp, Indianapolis, IN 46231 USA
Titolo Testata:
POLYCYCLIC AROMATIC COMPOUNDS
fascicolo: 4, volume: 18, anno: 2001,
pagine: 427 - 449
SICI:
1040-6638(2001)18:4<427:ISOETB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
COAL-TAR; CANCER RISK; ASPHALT WORKERS; INBRED STRAINS; SKIN; HUMANS; MICE; LUNG; CREOSOTE; AEROSOL;
Keywords:
bitumen; inhalation; DNA adducts; polycyclic hydrocarbons; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Castegnaro, M Les Collanges, F-07240 St Jean Chambre, France Les Collanges St Jean Chambre France F-07240 ambre, France
Citazione:
C. Genevois-Charmeau et al., "Inhalation study on exposure to bitumen fumes: Formation of DNA adducts invarious rat tissues following nose-only inhalation", POLYCYCL AR, 18(4), 2001, pp. 427-449

Abstract

During the hot application of bitumen containing materials, e.g., in hot paving or roofing, fumes are emitted that contain traces of polycyclic aromatic compounds (PACs) including heterocyclic and/or substituted PACs. Previous studies of DNA adduct formation by bitumen and coal-tar fume condensates(BFCs and CTFCs, respectively) indicated that the genotoxic compounds responsible for DNA adduct formation in BFCs and CTFCs were of different nature. Moreover, it was suggested that the major adduct found in the lungs and also in skin and lymphocytes of BFC-treated rats might be usable as a markerof exposure to bitumen fumes.

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Documento generato il 29/09/20 alle ore 23:32:31