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Titolo:
Studies on pig blood platelet responses to peroxynitrite action
Autore:
Nowak, P; Wachowicz, B;
Indirizzi:
Univ Lodz, Dept Gen Biochem, PL-90237 Lodz, Poland Univ Lodz Lodz PolandPL-90237 , Dept Gen Biochem, PL-90237 Lodz, Poland
Titolo Testata:
PLATELETS
fascicolo: 6, volume: 12, anno: 2001,
pagine: 376 - 381
SICI:
0953-7104(200109)12:6<376:SOPBPR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; TYROSINE NITRATION; SUPEROXIDE; AGGREGATION; ACTIVATION; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Nowak, P Univ Lodz, Dept Gen Biochem, Banacha 12-16, PL-90237 Lodz, PolandUniv Lodz Banacha 12-16 Lodz Poland PL-90237 -90237 Lodz, Poland
Citazione:
P. Nowak e B. Wachowicz, "Studies on pig blood platelet responses to peroxynitrite action", PLATELETS, 12(6), 2001, pp. 376-381

Abstract

The action of peroxynitrite (ONOO-) on pig blood platelet function was studied. Incubation of washed blood platelets with ONOO- (0.062-2 mM) caused strong, dose- and time-dependent inhibitory effects on adhesion of resting and thrombin-stimulated platelets to collagen and on platelet aggregation induced by thrombin. The platelet responses were measured 10 s after additionof peroxynitrite to platelets ('zero time') and after 60 min incubation ofplatelets with ONOO-. Exposure of blood platelets to peroxynitrite (60 min) brought about platelet lipid peroxidation assessed by the thiobarbituric acid method but did not cause any changes in blood platelet proteins as determined by SDS-polyacrylamide gel electrophoresis.

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Documento generato il 30/03/20 alle ore 09:54:25