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Titolo:
Gene expression following acute morphine administration
Autore:
Loguinov, AV; Anderson, LM; Crosby, GJ; Yukhananov, RY;
Indirizzi:
Univ Calif Berkeley, Dept Nutr Sci & Technol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 Technol, Berkeley, CA 94720 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Pain Res Ctr, Neurogenom Lab, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 genom Lab, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Gene Array Technol Ctr, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 chnol Ctr, Boston, MA 02115 USA
Titolo Testata:
PHYSIOLOGICAL GENOMICS
fascicolo: 3, volume: 6, anno: 2001,
pagine: 169 - 181
SICI:
1094-8341(200108)6:3<169:GEFAMA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA LEVELS; RAT-BRAIN; HIPPOCAMPUS; ADDICTION; SUBUNITS; NALOXONE; MODEL; MICE;
Keywords:
opioids; cDNA microarray; regression analysis; cluster analysis; spinal cord; striatum; skeletal protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Yukhananov, RY Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesia, MRB 611,75 Francis St, Boston, MA 02115 USA Harvard Univ MRB 611,75 Francis St Boston MA USA 02115 USA
Citazione:
A.V. Loguinov et al., "Gene expression following acute morphine administration", PHYSIOL GEN, 6(3), 2001, pp. 169-181

Abstract

The long-term response to neurotropic drugs depends on drug-induced neuroplasticity and underlying changes in gene expression. However, alterations in neuronal gene expression can be observed even following single injection. To investigate the extent of these changes, gene expression in the medial striatum and lumbar part of the spinal cord was monitored by cDNA microarray following single injection of morphine. Using robust and resistant linearregression (MM-estimator) with simultaneous prediction confidence intervals, we detected differentially expressed genes. By combining the results with cluster analysis, we have found that a single morphine injection alters expression of two major groups of genes, for proteins involved in mitochondrial respiration and for cytoskeleton-related proteins. RNAs for these proteins were mostly downregulated both in the medial striatum and in lumbar part of the spinal cord. These transitory changes were prevented by coadministration of the opioid antagonist naloxone. Data indicate that microarray analysis by itself is useful in describing the effect of well-known substanceson the nervous system and provides sufficient information to propose a potentially novel pathway mediating its activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 12:25:32