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Titolo:
In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies
Autore:
Cheung, C; Culver, JP; Takahashi, K; Greenberg, JH; Yodh, AG;
Indirizzi:
Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 & Astron, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Neurol, Cerebrovasc Res Ctr, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 c Res Ctr, Philadelphia, PA 19104 USA
Titolo Testata:
PHYSICS IN MEDICINE AND BIOLOGY
fascicolo: 8, volume: 46, anno: 2001,
pagine: 2053 - 2065
SICI:
0031-9155(200108)46:8<2053:IVCMCD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; LASER-DOPPLER MEASUREMENTS; HUMAN-BRAIN-FUNCTION; NITRIC-OXIDE; LIGHT; RATS; SCATTERING; MEDIA; MICROCIRCULATION; PERFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Cheung, C Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Philadelphia, PA 19104 USA
Citazione:
C. Cheung et al., "In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies", PHYS MED BI, 46(8), 2001, pp. 2053-2065

Abstract

We combine two near-infrared diffuse optical techniques to study variations of blood flow, haemoglobin concentration, and blood oxygen saturation in the functioning rat brain. Diffuse correlation spectroscopy (or flowmetry) monitors changes in the cerebral blood flow, without the use of the principles of tracer clearance, by measuring the optical phase-shifts caused by moving blood cells. Near-infrared absorption spectroscopy concurrently measures tissue absorption at two wavelengths to determine haemoglobin concentration and blood oxygen saturation in this same tissue volume. This optical probe is non-invasive and was employed through the intact skull. The utility of the technique is demonstrated in vivo by measuring the temporal changes in the regional vascular dynamics of rat brain during hypercapnia. Temporaland spatial variations of cerebral blood flow, haemoglobin concentration and blood oxygen saturation during hypercapnia are compared with other measurements in the literature, and a quantitative analysis demonstrating the self-consistency of our combined observations of vascular response is presented.

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Documento generato il 20/10/20 alle ore 04:43:06