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Titolo:
An evaluation of the hemostatic effects of hydrophilic, alcohol, and lipophilic extracts of notoginseng
Autore:
White, CM; Fan, CD; Song, J; Tsikouris, JP; Chow, M;
Indirizzi:
Hartford Hosp, Drug Informat Ctr, Dept Pharm, Ishikari, Hokkaido 06102, Japan Hartford Hosp Ishikari Hokkaido Japan 06102 hikari, Hokkaido 06102, Japan Univ Connecticut, Sch Pharm, Storrs, CT USA Univ Connecticut Storrs CT USA iv Connecticut, Sch Pharm, Storrs, CT USA Chinese Univ Hong Kong, Dept Pharm, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China
Titolo Testata:
PHARMACOTHERAPY
fascicolo: 7, volume: 21, anno: 2001,
pagine: 773 - 777
SICI:
0277-0008(200107)21:7<773:AEOTHE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANAX-NOTOGINSENG; SAPONINS; CELLS; R1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: White, CM Hartford Hosp, Drug Informat Ctr, Dept Pharm, Ishikari, Hokkaido06102, Japan Hartford Hosp Ishikari Hokkaido Japan 06102 kkaido 06102, Japan
Citazione:
C.M. White et al., "An evaluation of the hemostatic effects of hydrophilic, alcohol, and lipophilic extracts of notoginseng", PHARMACOTHE, 21(7), 2001, pp. 773-777

Abstract

Study Objective. To compare the hemostatic effects of hydrophilic, alcohol, or lipophilic extract of notoginseng with those of the control and placebo. Design. Hemorrhagic rat model. Setting. Hartford Hospital, Hartford, Connecticut; animals were housed at the Hartford Hospital animal facilityAnimals. Sixty-two male Wistar rats. Intervention. Administration of placebo (wheat flour), and alcohol, hydrophilic (water), and lipophilic (hexane) extracts of notoginseng. Methods. Rats were divided into five groups, and their tails were transected 5 mm from the tip. Group I received no treatment (control), group 2 received placebo, group 3 received alcohol extract, group 4 received hydrophilic extract, and group 5 received lipophilic extract. Total bleeding time wasdetermined and compared among the groups. Main Results. Bleeding time was shorter for the placebo group than the control group (p = 0.035). The alcohol extract group had the shortest bleedingtime, which was significantly shorter than that of the control (p < 0.0001), placebo (p = 0.0124), and lipophilic extract groups (p = 0.002). The hydrophilic extract group had a shorter bleeding time than the control group (p = 0.0058) and showed a trend toward shorter bleeding time than the lipophilic extract group (p = 0.068). Conclusions. The alcohol extract of notoginseng results in the shortest bleeding time and provides better hemostatic effects than no treatment, placebo treatment, and treatment with lipophilic extract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:36:31