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Titolo:
Cell-specific expression of manganese superoxide dismutase protein in the lungs of patients with respiratory distress syndrome, chronic lung disease,or persistent pulmonary hypertension
Autore:
Asikainen, TM; Heikkila, P; Kaarteenaho-Wiik, R; Kinnula, VL; Raivio, KO;
Indirizzi:
Univ Helsinki, Hosp Children & Adolescents, HUCH 00029, Helsinki 00250, Finland Univ Helsinki Helsinki Finland 00250 HUCH 00029, Helsinki 00250, Finland Univ Oulu, Dept Internal Med, SF-90220 Oulu, Finland Univ Oulu Oulu Finland SF-90220 ept Internal Med, SF-90220 Oulu, Finland
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 3, volume: 32, anno: 2001,
pagine: 193 - 200
SICI:
8755-6863(200109)32:3<193:CEOMSD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIOXIDANT ENZYME-ACTIVITY; BRONCHIAL EPITHELIAL-CELLS; HYALINE-MEMBRANE DISEASE; TUMOR-NECROSIS-FACTOR; BRONCHOPULMONARY DYSPLASIA; MESSENGER-RNA; RAT LUNG; DEVELOPMENTAL PROFILE; HYPEROXIC EXPOSURE; PREMATURE RABBITS;
Keywords:
antioxidant; lung development; oxygen; superoxide dismutase; ventilator treatment; respiratory distress syndrome; chronic lung disease; persistent pulmonary hypertension; lung defense; bronchopulmonary dysplasia; neonates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Asikainen, TM Univ Helsinki, Hosp Children & Adolescents, HUCH 00029, POB 280,Lastenlinnantie 11 C 29, Helsinki 00250, Finland Univ Helsinki POB 280,Lastenlinnantie 11 C 29 Helsinki Finland 00250
Citazione:
T.M. Asikainen et al., "Cell-specific expression of manganese superoxide dismutase protein in the lungs of patients with respiratory distress syndrome, chronic lung disease,or persistent pulmonary hypertension", PEDIAT PULM, 32(3), 2001, pp. 193-200

Abstract

The developmental profile of manganese superoxide dismutase (MnSOD) and its regulation in hyperoxia vary between species. We hypothesized that MnSOD increases in human lung in response to oxygen treatment, although this response could be restricted to certain cell types and depend on gestational age. Therefore, the cell-specific expression of pulmonary immunoreactive MnSOD protein was investigated during development, and in patients with respiratory distress syndrome (RDS), chronic lung disease (CLD), or persistent pulmonary hypertension (PPHN). Throughout ontogenesis, all cell types expressed MnSOD, but the most intense positivity was found in bronchiolar epithelium and (pre-) type-II pneumocytes. MnSOD protein did not increase during development. The MnSOD staining pattern in arterial endothelium was more intense in RDS patients than in age-matched controls, but this may be related to induction of MnSOD by increased blood flow rather than by oxygen. MnSOD expression in other cell types of RDS, CLD, or PPHN patients did not differ from that in age-matched controls. We conclude that, in terms of mitochondrial enzymatic superoxide scavenging capacity, preterm infants are not more vulnerable than term infants to oxygen-induced lung injury at physiological oxygen concentrations. However, the inability to induce MnSOD in response to oxygen treatment may result in a poor outcome. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:41:38