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Titolo:
Analogues of bleomycin: Synthesis of conformationally rigid methylvalerates
Autore:
Rishel, MJ; Hecht, SM;
Indirizzi:
Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA Univ Virginia Charlottesville VA USA 22901 Charlottesville, VA 22901 USA Univ Virginia, Dept Biol, Charlottesville, VA 22901 USA Univ Virginia Charlottesville VA USA 22901 Charlottesville, VA 22901 USA
Titolo Testata:
ORGANIC LETTERS
fascicolo: 18, volume: 3, anno: 2001,
pagine: 2867 - 2869
SICI:
1523-7060(20010906)3:18<2867:AOBSOC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-AMINO ALDEHYDES; SELECTIVE DNA CLEAVAGE; STEREOSELECTIVE SYNTHESIS; SECONDARY STRUCTURES; ALDOL CONDENSATIONS; GROUP ANTIBIOTICS; BETA-PEPTIDES; SIDE-CHAINS; ACIDS; A(2);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hecht, SM Univ Virginia, Dept Chem, Mccormick Rd, Charlottesville, VA 22901 USA Univ Virginia Mccormick Rd Charlottesville VA USA 22901 2901 USA
Citazione:
M.J. Rishel e S.M. Hecht, "Analogues of bleomycin: Synthesis of conformationally rigid methylvalerates", ORG LETT, 3(18), 2001, pp. 2867-2869

Abstract

[GRAPHICS]Several conformationally rigid analogues of the methylvalerate subunit contained within the linker domain of the antitumor antibiotic bleomycin have been prepared. These compounds have been protected in a fashion suitable for the solid-phase synthesis of bleomycin. Bleomycin congeners containing these analogues should facilitate a more detailed understanding of the natureof the conformational bend that the methylvalerate moiety is thought to impart to the natural product.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:50:22